Principal Research Associate, Gene Therapy Research

Location
Cambridge
Posted
Jul 23, 2021
Ref
5045917002
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is looking to expand our team with enthusiastic individuals to forward our novel targeted gene therapy platform. You will be working in a vibrant research environment with cross-functional connections to technical operations and gene therapy groups. You would work to advance the creative vision around our gene therapy platform with an emphasis on making gene therapies accessible to all patients who need them. This role reports to the Associate Director, Protein Engineering.

DUTIES AND RESPONSIBILITIES

Develop Sana gene therapy platform and build analytical understanding of its mechanisms of action.
  • Lead hypothesis-driven investigations into mammalian cell biological mechanisms that regulate delivery of our gene therapy platform.
  • Lead diverse assay development for characterizing novel vectors that support our platform.
  • Experimental design and testing of novel constructs utilizing high-throughput automation for mammalian cell transduction readouts (including flow cytometry and imaging techniques).
  • Understand and apply relevant scientific literature to the design of experimental protocols.
  • Interface with our Technical Operations team share vector production and analytics learnings
  • Work with our Technology Sciences team to facilitate tracking and mining of large datasets.
  • Maintenance of detailed electronic lab notebook and registration of constructs and biologics.
  • Following Standard Operating Procedures and developing new protocols when necessary.
  • Provide mentorship to others by leading in presentations and scientific discussion.
  • Demonstrate Sana's core values and the attributes that support these core values (Lead from every seat, Thrive as a team, Make it happen).

QUALIFICATIONS

Basic Qualifications

Bachelors plus 5+ years laboratory experience in an academic or industry setting, or Masters Degree in related field (Biology, Biochemistry, Engineering) with at least 3+ years with laboratory experience in an academic or industry setting.
  • A strong self-starter, independent thinker, with a strong attention to detail.
  • Advanced experience with developing a diverse range of assays (molecular, particle characterization, flow cytometry, and microscopy, among others).
  • Experience producing and analyzing viral vectors.
  • Well versed in a wide array of laboratory techniques, with emphasis on mammalian cell biological methods, and experienced in their use.
  • Excellent oral and written communication skills, attention to detail and data quality, and experience working on diverse collaborative teams.
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.

Preferred Qualifications
  • Demonstrated ability in working in a fast-paced, collaborative, and technical environment.
  • Excellent bench skills with attention to detail for data integrity and quality.
  • Understanding of mammalian molecular biology and cell biology.
  • Excellent communication and presentation skills, capable of conveying technical information in a clear and thorough manner.

PHYSICAL REQUIREMENTS
  • Carrying, handling and reaching for objects up to 25 lbs
  • Prolonged standing and/or sitting
  • Exposure to hazardous/toxic/dangerous chemicals
  • Manual dexterity required to operate office and lab equipment


To perform this job successfully, you must be able to perform each job responsibility satisfactorily. The job description listed above is representative of the knowledge, skills, and/or abilities required for this position. Reasonable accommodations may be made to enable individuals with disabilities to perform the functions described above.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

We are committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short- and long-term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.