Research Associate, Upstream Process Development

Location
Emeryville, CA
Posted
Jul 23, 2021
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Contract
4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT is currently conducting three clinical trials: 4D-125 is in a Phase 1/2 clinical trial for XLRP, 4D-110 is in a Phase 1 clinical trial for choroideremia and 4D-310 is in a Phase 1/2 clinical trial for Fabry disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

GENERAL SUMMARY:
We seek a talented and passionate Research Associate (contract) to join our leading-edge Upstream Process Development team in developing reagents & platforms for AAV production. This person will report to the head of Upstream Process Development.
Responsibilities:
  • Lab & Experimental Activities: 75%
  • Design and perform experiments across multiple unit operations including cell expansion, transient plasmid transfection, AAV harvest and sterile filtration.
  • Develop and test high-throughput in-process analytics for screening clonal cell lines and/or platform process improvements.
  • Support evaluation of early research candidates through material production.
  • Help evaluate and troubleshoot new technologies as well as continuous improvement projects.
  • Learn the operations of and help execute studies for AAV production in multiple bioreactor systems.
  • Draft and update process records, electronic lab notebooks (ELN) and technical reports. Generate technical documentation that is IND-supporting and will be communicated to relevant internal/external stakeholder &/or regulatory parties.
  • Cross-train on analytical methods, including DLS, PCR and ELISA-based methods, to support high-throughput process development studies.
  • Cross-functional & Communication: 25%
  • Collaborate with process & analytical teams to screen, generate and evaluate drug candidates across a range of indications.
  • Troubleshoot processes & equipment problems; work with Facilities to assist with maintenance and instrument operation requirements.
  • Contribute to a culture that embraces continuous learning, improvement and innovation. Work with others to expand their technical skill base and deepen their gene therapy expertise.
  • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time.

Qualifications:
  • Bachelor’s in Bioengineering, Biology, Biochemistry, Life Sciences or related field and relevant experience
  • Skills:
  • Asceptic cell culturing is required.
  • Experience with Excel, Word, PowerPoint and similar software.
  • Excellent organizational skills and attention to detail in the lab and with record upkeep.
  • Interest in developing strong communication skills, both written and oral; highlight presentation & communication of ideas in one on one discussions and team meetings.
  • Ability to work independently and in a team environment.
  • Experience working with plasmid sequences is a plus.
  • Working knowledge of GMP & GDP is a plus.
  • Physical Requirements of the Role:
  • In lab and lab support activities may require occasional manuevering of items approx. 25 lbs during operations and/or storage of consumables.
  • Prolonged periods of standing or sitting at the laboratory bench.
  • Must be willing to conform with the safety and social distancing practices established by 4DMT as well as the upstream PD group while on-site (4-5 days/week).
  • During COVID-19, this person will need to be in the lab up to five days a week and adhere to the 4DMT Covid protocols and policy.

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities