Director, Translational Medicine
At Arch Oncology, we are aiming high to discover and develop new antibody therapeutics to treat patients living with cancer. We are committed to advancing antibodies with best-in-class potential.
Our next-generation anti-CD47 antibodies are highly differentiated, with the potential to improve upon the safety and efficacy profile relative to other agents in this class. Our antibodies work by blocking the “don’t eat me” signal, the standard mechanism of anti-CD47 antibodies. Beyond blocking this signal, our antibodies also directly kill tumor cells. Importantly, our antibodies bind preferentially to tumor cells, instead of to normal cells, and bind even more potently to tumors in their acidic microenvironment (low pH).
Expanding our fight against cancer, we have advanced our lead anti-CD47 antibody AO-176 into clinical development for the treatment of patients with solid tumors.
We are aiming high in our fight against cancer. We are a team of highly experienced and driven professionals who are committed to excellence in all that we do. Our leadership team has successfully developed new drugs before. We know what we need to do to collaborate and execute to get the job done.
If you share this commitment and want to work with a team that is focused on helping patients, come aim high with us and apply.
At Arch Oncology, we have two locations. Our headquarters is in Brisbane, CA, a gateway of biotechnology innovation, and our scientific research laboratory is in St. Louis, MO, home of the Gateway Arch. This position is in Brisbane, CA.
VP, Translational Medicine
Arch Oncology has an exciting opportunity for an experienced and highly motivated Director of Translational Medicine. Reporting to the Vice President of Translational Medicine, the candidate will work closely with the clinical development and research teams on biomarker and translational strategies. The strong candidate will have a background in immunology or immune-oncology and be self-motivated, creative, independent, collaborative and a strategic thinker with deep scientific rigor and a proventranslational science track record.
Job Description and Responsibilities:
- Develop and implement biomarker components of clinical trials, including protocol development and execution of translational plans
- Evaluate and rigorously interpret biomarker data to demonstrate pharmacodynamics, and mechanisms of response and resistance for reverse translation
- Develop and execute relevant translational strategies with internal and external collaborators
- Utilize available data to propose biomarker strategies for molecules in development that align with clinical biomarker strategies
- Identify and manage academic and contract partners to achieve translational goals
- Evaluate CROs for assay and technology platforms
- Lead/oversee biomarker assay identification, development and validation for clinical trial implementation
- Maintain routine and close partnership with translational operations to ensure integration of scientific and clinical strategy with sample collection, processing, storage and data transfer
- Collaborate with external experts for implementation and data analysis of PK and toxicology studies
- Coauthor reports, scientific communication materials, and manuscripts
- Communicate internally and externally by preparing and delivering presentations to senior leadership, colleagues and external audiences
Position Requirements and Experience:
- Ph.D (or M.S. in unique situations) in immunology, cell biology or cancer biology, or related field with 8+ years of experience in the biotechnology or pharmaceutical industry, including 5+ years focused on biologics, oncology and immune oncology programs from a translational medicine perspective
- Broad understanding of the drug discovery pipeline, from research through clinical development
- Proven ability to rigorously analyze and interpret scientific data independently
- Motivated, flexible, results-oriented self-starter, who enjoys working in a fast-paced, dynamic team environment and who is accountable for timelines and deliverables
- Prior experience with clinical trial/informed consent documents and designing biomarker strategies
- Prior experience acquiring and analyzing PK and exploratory data from clinical trials and integrating with clinical endpoints to ensure impact on development program
- Experience with data analysis tools and ways to optimize data visualization are required (Excel,Spotfire, Prism)
- Familiarity with data analysis from immunohistochemical (simple and multiplex), flow-based, multiplex ELISA and gene expression assays
- Outstanding verbal and written communication skills, and excellent organizational skills
- Non-clinical pharmacology and toxicology experience a plus
Arch Oncology offers a generous benefit package including medical, dental, vision, and disability insurance, as well as paid time off and a 401k plan.
Arch Oncology is an Equal Opportunity Employer and does not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class.