Research Associate, Discovery (High-throughput Mammalian Screening)

Brisbane, CA, United States
Jul 22, 2021
Science/R&D, Research
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences is advancing disease detection and treatment using its novel CRISPR systems that can deliver on the promise of precision medicine across diagnostics and therapeutics. Furthermore, Mammoth's CRISPR technology platform will enable new solutions in life science research, healthcare, agriculture, biodefense and more.

Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber.


Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.OPPORTUNITY

Mammoth is currently seeking a creative and detail-oriented Research Associate with experience in molecular biology, next-generation sequencing, and/or mammalian cell culture to join our growing Discovery team.


Mammoth is currently seeking a creative and detail-oriented Research Associate with experience in molecular biology, next-generation sequencing, and/or mammalian cell culture to join our growing Discovery team.

The successful candidate will work collaboratively with colleagues to develop and execute high-throughput experiments on mammalian cell lines to support the discovery, characterization, and development of novel Cas nucleases for genome editing. They will have the opportunity to contribute broadly across multiple technical areas, including automation, software tool development, synthetic biology, and high-throughput screening.

This position requires adaptability, strong organizational and communication skills, and the ability to work both independently and collaboratively in a dynamic team-oriented environment.

    • Develop and execute high-throughput molecular biology, cell culture, and functional assay protocols in the novel Cas nuclease discovery pipeline
    • Integrate high-throughput laboratory automation into experimental workflows
    • Detailed, accurate, and timely documentation of experimental procedures, data, and analysis, including meticulous sample tracking and data management
    • Provide team support for basic laboratory tasks including tissue culture of various cell lines, phenotyping and analytical characterization of cells, genome editing of human cells, and virus production
    • Regular communications of data and analysis results to senior staff and team members
    • Conduct all activities in a safe and efficient manner, adhering to environmental health and safety requirements

    • Bachelor's degree in molecular and cell biology, immunology, biochemistry, or a related field
    • 2 years of research experience with mammalian cell culture or in molecular/cell biology

    • Experience or proficiency in mammalian cell culture, molecular cloning, PCR, DNA/RNA purification, and next-generation sequencing
    • Experience with high-throughput laboratory automation (e.g. Tecan liquid handlers, Agilent Bravo, ZAG)
    • Experience or proficiency with SQL, R, Python, etc. as well as other data analysis tools such as JMP, FlowJo, etc.
    • 2 years of biotechnology industry experience

    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching

It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.