Laboratory Automation Scientist
- Employer
- Nurix Therapeutics
- Location
- San Francisco, CA, United States
- Start date
- Jul 22, 2021
View more
- Discipline
- Engineering, Automation Engineer, Science/R&D, Research, Laboratory
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Biotech Bay
Job Details
- Compound registration
- Sample Management and Curation
- Management of chemical building blocks
You will enable chemists, biologists, assay scientists and management to track compounds, plates and libraries as they progress from idea through synthesis, purification, analysis and testing to have accurate inventory availability information and provide rapid access to compounds for testing.
Responsibilities
- Routinely operate liquid handling instrumentation (Hamilton, Tecan, Gilson, Optron, Agilent, or other automation platforms) to produce master compound plate formats for distribution.
- Provide operational support for inventory control, receiving, registration, weighing, storing, sorting, inventory maintenance, labeling, distribution, and disposition of the Nurix compound collection and other critical reagents.
- Shipping preparation for requested compounds throughout R&D departments and to CRO's.
- Process sample requests for distribution, record transactions and maintain proper documentation.
- Integrate laboratory instrumentation with LIMS and inventory management systems.
- Troubleshoot and resolve basic liquid handler system errors and recover operations.
- Perform liquid handler performance monitoring and other laboratory equipment maintenance.
- Keep an inventory of supplies used to manage samples and order supplies when needed.
- Assist with the maintenance, operation and support of sample storage equipment and the associate monitoring system.
- Design, plan, develop and execute routine Inventory Audit processes to maintain the Nurix Compound collection inventory accuracy.
Required Qualifications
- BS or higher in Life Sciences Fields (Chemistry preferred)
- Minimum 5 years experience with at least one of the following industry standard applications such as ChemCart, Dotmatics, GeneData, Benchling, Sample Manager, LabWare, and/or LabVantage
- Experience in the development, optimization, and preparation of biochemical assay plates
- Familiarity authoring requirements/specifications, workflow/process diagrams, and project plans.
- Technical knowledge and experience with laboratory automation and compound processing and tracking, including knowledge and use of Laboratory Information Management Systems (LIMS) and integration of individual hardware components into automated environments is desired.
- Solid understanding and demonstrated functional use of RDBMS and programming:
- Understanding and use of SQL or basic API filtering of compound data
- Visual Basic/VBA or other Instrument macro programming experience (Python/Perl/Java)
- Excellent verbal and written communication skills
- Expertise in MS Office (Excel, Word, PowerPoint, Visio)
- Minimum 2 years experience programming Liquid Handlers (Hamilton, Tecan, Gilson, Agilent etc.)
- Familiarity with plate preparations for Acoustic Liquid handlers such as the Labcyte Echo.
Desirable Experience
- Solid understanding of chemical classification, computerized chemical representation and familiarity with SDF file formats, organization and use for inventory import/export operations.
- Hierarchical data management of inventory with an understanding of relational links, constraints, required information and how it interacts with LIMS data structures and underlaying tables.
- Familiarity with open access instrument operation
Company
Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.
Company
Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix’s extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix’s drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.
Nurix’s wholly owned pipeline comprises targeted protein degraders of Bruton’s tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.
- Website
- https://www.nurixtx.com/
- Phone
- 415-660-5320
- Location
-
1700 Owens Street
Suite 205
San Francisco
California
94158
US
Get job alerts
Create a job alert and receive personalized job recommendations straight to your inbox.
Create alert