Senior Principal Research Scientist / Associate Director, DMPK

Location
South San Francisco, California
Posted
Jul 22, 2021
Ref
B2CEA23088
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time

About IDEAYA Biosciences:

IDEAYA Biosciences (NASDAQ: IDYA) is a public, clinical-stage oncology-focused precision medicine company committed to the discovery and development of targeted therapeutics for patient populations selected using DNA sequencing and other molecular diagnostics. Our approach integrates extensive capabilities in identifying and validating translational biomarkers with small molecule drug discovery to select patient populations most likely to benefit from the therapies we are developing. We are applying these capabilities across multiple classes of precision medicine, including direct targeting of oncogenic pathways and synthetic lethality – which represents an emerging class of precision medicine targets. We believe this diversified approach will enable us to deliver the right medicine to the right patient to drive a more robust clinical response.

IDEAYA recently announced a landmark strategic partnership with GSK in Synthetic Lethality for certain pipeline programs. The GSK partnership is transformative and enables IDEAYA and GSK to collectively build an industry leading platform and pipeline in Synthetic Lethality. For more information, please see www.ideayabio.com.

The Opportunity:

We are seeking a talented and highly motivated Senior Principal Research Scientist/Associate Director with significant pharmaceutical industry experience to join our multidisciplinary team based in South San Francisco. The individual will lead the ADME and DMPK project strategy, design and execute both in vitro and in vivo non-clinical studies, and provide insight into PK/PD in a highly collaborative multi-disciplinary environment. The candidate will represent their function on core pre-clinical discovery and development project teams and work within relevant sub-teams to ensure tactical alignment and execution. He/she will guide clinical pharmacology and PK/PD modeling strategy and oversee IND enabling studies in areas of ADME, DMPK, PK/PD and toxicokinetics.

Responsibilities:

  • Serve as the subject matter expert for DMPK during all stages of drug discovery and early development
  • Design and oversee non-clinical ADME studies; make pertinent recommendations to project teams to solve ADME issues
  • Participate in study design, vendor selection, study execution, interpretation and report writing for molecules that pertain to PK and PK/PD assessment in research and development
  • Conduct pharmacokinetic & pharmacodynamic data analysis and modeling
  • Initiate and facilitate collaborations with external partners, biology, and pharmacology colleagues in support of PKPD; outsource and manage ADME and DMPK studies at CROs
  • Author report/sections for regulatory filings, i.e., IND and IB.
  • Play a critical role in the selection of lead compounds and nomination of development candidates, collaborating closely with Medicinal Chemistry, Biology, CMC, Pharmacology and Toxicology
  • Establish DMPK strategies that align with program goals and strive for high quality drug candidates
  • Effectively communicate DMPK data and their relevance to multidisciplinary project teams, management, regulatory authorities, and potential partners
  • Prepare preclinical DMPK reports according to regulatory standards

Requirements

Qualifications:


  • Ph.D. in pharmacokinetics, drug metabolism, or related discipline with a minimum of 7 years of relevant industrial experience in the evaluation of small molecule therapeutics
  • Broad understanding of DMPK concepts and relevant areas such as physicochemical properties, drug metabolizing enzyme and transporter kinetics, pharmacokinetics, biotransformation and analytical sciences
  • Broad understanding of drug discovery and development, especially in oncology
  • Ability to multi-task in a fast-paced dynamic environment while demonstrating a calm and positive attitude and a superior work ethic
  • Dynamic and innovative scientist with a well-developed sense of teamwork. They will have the interpersonal skills required to communicate effectively with external collaborators and internal project teams
  • Broad understanding of PKPD concepts
  • Hands-on modeling experience using Phoenix Winnonlin, Gastroplus, ADAPT or similar software
  • Ability to translate data into project relevance as part of anticipating and/or mitigating project challenges
  • Evidence of leadership in the DMPK field and a proven track record of scientific achievement & project influence, including ability to influence external scientific and regulatory practices through publication and other interactions
  • Excellent verbal and written communication skills as well as strong interpersonal skills are essential

Benefits

When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

Ideaya is an equal opportunity employer. In accordance with applicable law, Ideaya does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/V

Benefits

When you're at IDEAYA, you will be in the midst of brilliant minds working on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine, which means we all have a high internal drive that is at the very core of every person at IDEAYA. We are inquisitive, ask deep questions, and are data-driven innovators who like to collaborate and use team work to move science forward.

Ideaya is an equal opportunity employer. In accordance with applicable law, Ideaya does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets.