Senior Scientist/Associate Director, Lead Discovery

San Francisco, CA, United States
Jul 21, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

The Position

We are seeking an experienced biochemist to lead our small molecule profiling group at Nurix. As leader of this group you will work collaboratively on multiple programs, partnering with your peers across Nurix's discovery platform, including Protein Sciences, DNA Encoded Chemistry and Screening, Medicinal Chemistry, Cellular Biology, and in vivo Pharmacology to identify, characterize and advance novel small molecules directed against a range of therapeutic targets.

  • Responsible for leading an internal team of 3-5 scientists in the development and implementation of biochemical assays to support on-going small molecule discovery efforts
  • Contribute to the design and development of assays for the characterization of protein-protein and enzymatic activities of therapeutic targets across a wide range of protein families and functions and manage the application of those assays for:
    • qualification of target proteins for DNA encoded library screens
    • hit confirmation and prioritization for follow up chemistry
    • advancement of lead molecules for heterobifunctional degrader synthesis
  • Development of biochemical assays to characterize and advance the degrader properties of heterobifunctional degrader molecules
  • Manage prioritization of the profiling activities within a matrixed organization, supporting multiple internal and external collaboration projects simultaneously
  • Communicate scientific results to internal and external stakeholders

  • Ph.D. in Biochemistry, Structural Biology, Biophysics or related field with 8+ years of post-degree experience
  • Expertise in the development and implementation of various biochemical and enzymatic assays for the characterization of protein activities and the effects of small molecules on those activities
    • Expertise in broad range of biochemical and biophysical techniques for assessing protein-protein and protein-small molecule interactions
    • In particular, experience in the use of time-resolved FRET and fluorescence polarization-based technologies is preferred
  • Demonstrated track record of successfully applying biochemical and biophysical characterization to the advancement of chemical matter through SAR improvement campaigns
  • Demonstrated ability to guide reports in the development and implementation of biochemical assays and a strong desire to grow and develop the careers of team members
  • Experience with drug discovery project leadership is preferred
  • Excellent written and oral communication skills
  • Aligned to Nurix's culture and values; team-oriented and highly collaborative with a hands-on approach