Research Associate III/Senior Research Associate, Lead Discovery

Location
San Francisco, CA, United States
Posted
Jul 21, 2021
Ref
5257836002
Discipline
Science/R&D, Research
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Position

We are seeking a highly motivated individual with a background in Biochemistry or Molecular Cell Biology to join our Lead Discovery team at Nurix.
  • Responsible for the development and optimization of biochemical assays to monitor the protein-ligand or enzymatic activity of target proteins
  • Implementation of those assays to quantify the activity and quality of proteins entering our DNA encoded library selection pipeline
  • Robotic automation of those assays to monitor the potency of large numbers of molecules in high-throughput fashion, guiding the validation and progression of screen hits in compound improvement campaigns
  • Working as part of highly collaborative project teams of biochemists, structural biologists, cell biologists, and medicinal chemists to advance small molecule modulators of therapeutic targets
    • Representation of the Lead Discovery function, helping to guide the biochemical assay development and reporting results back to the project teams

Qualifications
  • Bachelor's or master's degree in Biochemistry, Molecular and Cell Biology, or related field
  • 5+ years (Bachelor's) or 2+ years (Master's) of relevant experience
  • Experience developing and running biochemical assays to assess protein activity and monitor small molecule effects (e.g. enzymatic, ubiquitylation, protein-protein interaction, fluorescence polarization, TR-FRET, AlphaLISA, etc.)
  • Experience using robotic automation (e.g. acoustic dispensers, liquid handling platforms)
  • Protein purification (e.g. AKTA Purification of proteins from coli or SF9 cells)
  • Excellent organizational skills, attention to detail, and ability to multitask
  • Excellent oral and written communication
  • Strong desire to learn new techniques and the ability and interest to cross train in all aspects biochemical assay development
  • Experience and proficiency with data processing programs (i.e. Microsoft Excel, GraphPad Prism, ActivityBase, etc.)

Fit with Nurix Culture and Values
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Company

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.