Senior Scientist

Location
Emeryville, CA
Posted
Jul 21, 2021
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT is currently conducting three clinical trials: 4D-125 is in a Phase 1/2 clinical trial for XLRP, 4D-110 is in a Phase 1 clinical trial for choroideremia and 4D-310 is in a Phase 1/2 clinical trial for Fabry disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

GENERAL SUMMARY:
A Sr. Scientist role in the Human Cell and Disease Modeling group at 4DMT will lead preclinical in vitro pharmacology work for AAV gene therapy candidates to treat a variety of diseases. The role allows for extensive creativity, innovation and opportunity to generate various cell systems and develop novel disease models to examine tropism, function and characteristics of AAV gene therapy vectors.  A Sr. Scientist works closely with HCDM team members and peers in other R&D departments to lead scientific programs, exchange ideas, improve protocols and generate valuable data to drive 4DMT towards its goals. They will participate in cross functional meetings and present data in various company settings. They are required to be scientifically independent and lead programs with little oversight.
Responsibilities:
  • Lab Activities: 50%
  • Stem cell culture maintenance and reprogramming
  • Optimization of cell differentiation protocols in 2D and 3D culture systems
  • Ability to effectively design experiments to characterize cell models and determine tropism of AAV capsids
  • Development of functional assays to determine efficacy of lead AAV vectors
  • Draft study designs, protocols, differentiation paradigms and maintain an electronic lab notebook
  • Design directed experiments to meet strict timelines
  • Cross Functional/Communication: 30%
  • Contribute scientific ideas and knowledge in departmental and cross-functional team meetings
  • Effectively present findings at departmental and cross-functional team meetings
  • Engage in HCDM study design for various programs
  • Present annually at Research and Progress meeting
  • Help compile and write data sections for IND preclinical pharmacology reports
  • Communicate effectively with management and their team to achieve departmental goals
  • Management of Direct Reports: 20%
  • Effectively manage direct reports to produce data to meet departmental goals
  • Aid in scientific and career development of direct reports

Qualifications
  • Ph.D. in a relevant scientific field, preferably Cell and Molecular Biology
  • Experience:
  • 10+ years of experience within Biotech or similar industry
  • 8+ years of cell culture experience
  • 5+ years of stem cell culture maintenance and reprogramming experience
  • 2+ years management experience in Biotech or similar industry
  • Technical Skills
  • Expertise in cell culture: adherent, suspension, monolayer, 3D
  • Expertise in stem cell culture, maintenance, freezing and passaging
  • Fibroblast reprogramming into pluripotent stem cells through various non-integrating methods
  • Ability to develop and carry out differentiation of stem cells into various cell types
  • Protein identification through Western blotting, flow cytometry and immunocytochemistry
  • Development and optimization of functional assays for various cell types
  • Expertise in microscopy and using imaging software
  • Strong in molecular biology techniques and virus handling and transduction
  • Non-technical Skills
  • Understands integration of company and departmental goals
  • Leverage strategic organizational awareness for planning and timely delivery of assigned projects to meet departmental and company goals
  • Strong problem-solving skills to lead and deliver on multiple complex projects, and interact with external partners without supervision
  • Strong resiliency and a sense of ownership; effective prioritization skills, attention to detail and accuracy; adaptable, embraces and endorses change
  • Committed to offering innovation, finding opportunities to enhance ways of working (including processes, methods, technology etc.) and sharing new techniques and lessons learned pro-actively with peers
  • Influence as thought leader in your department and an influential subject matter expert to your team members and colleagues
  • Build and maintain strong working relationships with internal and external colleagues and partnerships with other data scientists and analysts, biostatistics, medical and business leaders, and other key functional experts
  • Act as a positive role model for peers and help coach colleagues to improve in their role with both technical and interpersonal skills
  • Excellent communication skills, effective management ability, constructive at giving and receiving feedback
  • Excellent time management organizational skills, with ability to handle multiple tasks simultaneously in a high-growth, fast-paced environment
  • Physical Requirements
  • Lifting no more than 20 lbs to help put away supplies
  • Ability to sit and work at a cell culture laminar flow hood and at a microscope for several hours at a time
  • During COVID-19, this person needs to be in a lab at least four times a week and adhere to 4DMT Covid protocols and policy

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities