Senior Research Associate

Location
Emeryville, CA
Posted
Jul 21, 2021
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT is currently conducting three clinical trials: 4D-125 is in a Phase 1/2 clinical trial for XLRP, 4D-110 is in a Phase 1 clinical trial for choroideremia and 4D-310 is in a Phase 1/2 clinical trial for Fabry disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

GENERAL SUMMARY:
A Senior Research Associate (SRA) role in the Human Cell and Disease Modeling group at 4DMT supports preclinical in vitro pharmacology work for AAV gene therapy candidates to treat various diseases. The role allows for extensive creativity, innovation, and opportunity to generate multiple cell systems and develop novel disease models to examine tropism, function, and characteristics of AAV gene therapy vectors.  An SRA works closely with HCDM team members and peers in other R&D departments to exchange scientific ideas, improve protocols and generate valuable data to drive 4DMT towards its goals. They will participate in cross-functional meetings and present data in various company settings.
Responsibilities:
  • Lab Activities: 70%
  • Stem cell culture maintenance and reprogramming
  • Optimization of cell differentiation protocols in 2D and 3D culture systems
  • Ability to design experiments to characterize cell models and determine tropism of AAV capsids
  • Assist in the development of functional assays to determine the efficacy of lead AAV vectors
  • Ability to review literature to aid in assay development and understand biology of cells and diseases of interest (10% of Lab Activities)
  • Draft study designs, protocols, differentiation paradigms and maintain an electronic lab notebook
  • Cross Functional/Communication: 30%
  • Present finding at departmental and cross-functional team meetings
  • Engage in HCDM study design for various programs
  • Contribute scientific ideas and knowledge in departmental and cross-functional team meetings
  • Contribute to the  annual HCDM Research and Progress meeting
  • Help compile data and write methods and results sections for IND preclinical pharmacology reports

Qualifications:
  • Bachelor’s degree in a relevant field, preferably Cell Biology
  • Experience:
  • 4+ years of experience within Biotech or similar industry
  • 4+ years of cell culture experience
  • 2+ years of stem cell culture maintenance and reprogramming experience
  • Cell differentiation protocol development
  • Skills:
  • Strong cell culture experience: adherent, suspension, monolayer, 3D
  • Stem cell culture, maintenance, freezing, and passaging
  • Fibroblast reprogramming into pluripotent stem cells through various non-integrating methods
  • Ability to assist in differentiation of stem cells into various cell types
  • Ability to read through and synthesize scientific literature to help develop novel cell differentiation protocols and identify and design functional assays for gene therapy vector testing
  • Can collaborate and work in a team of scientists, research associates, and program managers
  • Strong written and oral communication skills with some experience in presenting scientific information
  • Effective time management and organizational skills, with ability to handle multiple tasks simultaneously in a high-growth, fast-paced environment
  • Ability to meet deadlines and prioritize
  • Problem-solving, analytical skills, attention to detail, and creativity
  • Experience in supporting scientific initiatives
  • Ability to be part of a team and uphold 4DMT Guiding Principles
  • Physical Requirements:
  • Lifting no more than 20 lbs to help put away supplies
  • Ability to sit and work at a cell culture laminar flow hood and at a microscope for several hours at a time
  • During COVID-19, this person needs to be in a lab at least four times a week and adhere to 4DMT Covid protocols and policy

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities