Flow Cytometry Manager
Xencor is an innovative, clinical-stage biotechnology company located in the Los Angeles area (near Pasadena) and in San Diego. We use our pioneering XmAb® technologies to discover and develop better biotherapeutics – antibodies and other proteins with improved function – with the goal of improving patient outcomes and quality of life, and we have an excellent opportunity for an experienced Flow Cytometry Manager to join our Protein Sciences Group.
Our protein engineering capabilities and the modular nature of our technology allow us to quickly identify and create new platforms and drug candidates for potential development. We are developing a broad portfolio enabled by the rapid expansion of our bispecific technologies, and 10 XmAb bispecific antibodies and cytokines are in clinical testing. We also leverage our many XmAb technologies by engaging in collaborations with leading global biopharmaceutical companies for use in developing their own proprietary antibodies with improved properties. Including our partners, over 20 XmAb drug candidates are advancing through clinical development, and three medicines that incorporate XmAb technologies are marketed commercially.
Our employees are the most important factor in our success, and we have assembled a highly talented group from diverse backgrounds and disciplines to execute our business plan and shape our future. Xencor employees’ value new ideas and flexibility and demand from each other scientific rigor, a passion for innovation, and a willingness to take risks.
We currently have an excellent opportunity for a talented Flow Cytometry Manager to join our team!
Responsible for providing oversight of all aspects of flow cytometry research laboratory in a research laboratory environment, supporting a dynamic group of cellular immunologists.
- Ensures proper equipment safety and daily maintenance and operation of 6 cytometers (2 Fortessa, 3 Symphony, 1 Attune NxT) and 1 Melody sorter.
- Troubleshoots instrument problems in real-time including instrument performance and independently address root causes
- Communicates problems/solutions effectively across the department keeping stakeholders informed of instrument status
- Coordinates new technology evaluations, equipment purchases/installations, preventative maintenance or repairs services
- Provides technical guidance to internal functional groups/users
- Leads vendor engagements and contracts negotiations working in collaboration with subject matter experts, legal and finance departments
- Stays current with, interprets, and implements state of the art protocols
- Maintains inventory for flow-related supplies and consumables
- Participates in developing and refining flow cytometric assays with users and protocol troubleshooting
- Administers orientations, onboarding, and training for team members and assist
- Coordinates with facilities and EH&S colleagues for matters related to flow lab operations and safety
- Maintains and oversees instrument scheduling and use of shared equipment
- Participates in building and maintaining relationships across departments for space planning and resource sharing
- Works closely with senior leaders to ensure effective prioritization and optimal resource management across the team
- Performs other relevant responsibilities as assigned including limited wet lab bench research
- Performs other duties as required.
A Bachelor’s degree is required, with a graduate degree (M.S. or Ph.D.) preferred. In addition, a minimum of 6 years of relevant work experience is required.
Candidates with a Bachelor’s degree (only) will be considered if they also have at least 3 years of relevant lab managerial experience. Otherwise, 1 year of laboratory management experience required.
Position also requires:
- 6+ years of research lab experience that includes at least 3 years of direct multi-laser high throughput flow cytometry experience
- Ability to manage use of 6 flow cytometers with HTS (2 Fortessa, 3 Symphony, 1 Attune NxT) and 1 Melody sorter, with further growth anticipated.
- In-depth knowledge of sorting and cytometry including optics, data acquisition, fluidics and principles of fluorescence and experience with analysis and acquisition software (FACSDiva, Flowjo, BD FACSChorus, FCS Express or similar)
- Previous experience managing flow instruments in a core multi-user facility a plus
- Demonstrated experience with cellular phenotyping including human and nonhuman primate immune cells preferred
- Previous wet-lab research experience required
- Organized and detail-oriented manager with excellent time-management and problem-solving capabilities.
- Multi-tasker with demonstrated ability to work in a fast-paced and culturally diverse environment.
- Working knowledge of immunology and hands-on experience with immunoassays preferred.
- Strong verbal and written communication skills to work effectively with individuals and teams at various levels.
- Experienced working in a structured environment with emphasis on priorities, achieving specified objectives and tangible deliverables preferred.
- Strong collaborator who is hard-working, independent, adaptable, and dependable and willing to do what it takes to accomplish the task.
- Experience in setting up a new laboratory is highly desirable.
- Experience working in bioscience industry supporting diverse scientific teams to execute priorities across the discovery and development pipeline highly desirable.
Physical, Mental and Environment Demands:
The physical, mental and working environment demands described are representative of those that must be met by an employee to successfully perform the primary functions of this position.
The physical demands of the office are normally associated with extended amounts of time sitting and using office equipment, including a computer, keyboard and mouse, which can cause muscle strain. While performing the duties of this job, the employee is frequently required to stand, walk and sit. Periodic light lifting of supplies and materials may apply, and the incumbent may be required to lift and/or move up to 30 pounds.
Specific mental demands for the position are listed above under requirements. In addition, mental demands for this position include:
- Ability to multitask without loss of efficiency or accuracy, including the ability to perform multiple duties from multiple sources.
- Ability to work and sustain attention with distractions and/or interruptions.
- Ability to interact appropriately with a variety of individuals including vendors, customers and clients.
- Ability to maintain regular attendance and be punctual.
- Ability to understand, remember and follow verbal and written instructions.
Occasional travel may be required, including travel between Xencor’s Monrovia and San Diego offices. Work for this position is generally performed at Xencor’s worksite and requires full-time commitment.
Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.