Senior Scientist, In Vitro Pharmacology

Location
San Diego, CA, US
Posted
Jul 18, 2021
Ref
6041
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time
Overview

Imagine\u2026 2 weeks after the birth of your child you realize they aren't meeting critical developmental milestones and after months of doctor's appointments you are told your baby has a rare neurological disease that would impact how they would live their lives. This is the reality of parents whose children have Spinal Muscular Atrophy (SMA) and it's the reason why we at Novartis Gene Therapies are laser focused on bringing hope and possibility to those devastated by rare genetic diseases.

The Senior Scientist - In Vitro pharmacology, is responsible for leading activities in the In vitro pharmacology group, including developing and mentoring the team and supporting the advancement of research projects. This role works with Scientists within the Research and Development team, as well as across the organization and reports to the function head of In Vitro Pharmacology.

Responsibilities
  • Leverages strong understanding and knowledge of gene expression and cellular mechanism of action (MOA) for clinical candidate selection and cell-based assay development.
  • Designs and executes experiments to identify and optimize key parameters for cell potency assays for lot release (expression-based and functional).
  • Leads activities within the functional group for pipeline program R&D from both the bench and the desk.
  • Coordinates group efforts and oversee Scientists and ongoing projects to facilitate teamwork.
  • Manages and develops team members; ensuring staff receive mentoring and constructive feedback in order to develop in the role and learn new capabilities.
  • Partners with project team leaders to plan, coordinate, and monitor the timely execution and completion of various research projects.
  • Oversees the maintenance of accurate, comprehensible, and current laboratory notebooks.
  • Presents data to the internal senior management team and external collaborators.
  • Timely provision of data and documentation in reports to support intellectual property filings, regulatory submissions and interactions with FDA around new products.
  • Other relates duties as assigned.

Qualifications
  • Bachelor's in scientific area (biology, cell biology, pharmacology or related) with 8 years' relevant experience or Master's with 6 or PHD with 4.
  • Expert knowledge of scientific principles and concepts.
  • Extensive laboratory and working knowledge of cell biology and cell-based assays for potency (expression and MOA).
  • Publications and demonstrable experience desired.
  • Background in neuroscience.
  • Specific laboratory experience desired includes, but is not limited to:
    • Knowledge of viral gene therapy (adeno associated viral vectors).
    • Cell line development and characterization, cell culture and cell banking activities.
    • Genome editing, molecular cloning & DNA delivery methods.
    • Reporter and protein expression assays.
    • Human IPSC-derived neurons, fibroblasts and murine primary cell culture.
    • Biotechnology methods: High content imaging, Western blot, RT-qPCR, enzymatic assays, CRISPR, dsiRNA, ICC, ELISA, MSD, SIMOA, flow cytometry, NGS, RNA-seq, 10x.
  • Ability to work in a fast-paced small, but growing team environment and to prioritize work from multiple projects. Must be highly reliable and goals/deadlines oriented.
  • Up to 10% travel may be required


The level of this position will be based on the final candidate's qualifications.

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

Novartis Gene Therapies Benefit Summary:

Annual bonus, long term incentive, health insurance, paid vacation/holidays, potential flexible working arrangements (based on role) and an employee recognition program are available for this position, among many other benefits provided to employees of Novartis Gene Therapies.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Novartis Gene Therapies is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.

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