Head of Histology - Senior Principal Scientist

San Diego, CA, US
Jul 18, 2021
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time

Imagine\u2026 2 weeks after the birth of your child you realize they aren't meeting critical developmental milestones and after months of doctor's appointments you are told your baby has a rare neurological disease that would impact how they would live their lives. This is the reality of parents whose children have Spinal Muscular Atrophy (SMA) and it's the reason why we at Novartis Gene Therapies are laser focused on bringing hope and possibility to those devastated by rare genetic diseases.

The Head of Histology - Senior Principal Scientist, leads the experimental design and execution, analysis and interpretation of data, regular presentations of results and interpretation at project team and department meetings. This role oversees activities of the associates, aligning work with Program Team Leads, and managing and prioritizing work.

  • Builds efficiency and new capabilities in all aspects of histology to contribute to the discovery of novel gene therapies.
  • Directly supervise all Histology Team members.
  • Manages histology projects and priorities across Histology Team members.
  • Manages companywide project requests and provide cross-functional communication for histology-related projects to Project Team Leaders and Lead Scientists.
  • Works in collaboration with Pathologists to deliver material to access safety in preclinical studies
  • Develops and implements new assays, functionality, and technology to address project needs.
  • Oversees sample/data organization logistics and assay/data quality control.
  • Works hands-on in the lab to contribute to project execution: process tissue for histology and imaging.
  • Generates data using fluorescence microscopy, confocal microscopy, and whole slide scanners.
  • Writes formal study reports for submission to regulatory agencies.
  • Serves as technical resource, training and supervising other scientists in histology and equipment usage.
  • Manages equipment maintenance and calibration.
  • Other relates duties as assigned.

  • Bachelor's in Biology or related scientific area with 12 years' experience or Master's with 10 or PHD with 8 years' experience.
  • 6 years' experience as a histologist.
  • highly innovative and creative with relevant industry experience including basic histology, various staining and histochemical approaches, imaging, morphometry, quantitative analysis, experience with automated histology equipment, and reporting.
  • Demonstrated proficiency in histology and complex tissue analysis.
  • Experience with histological examination of neuronal tissues, whole brain slices, and brain substructure evaluation preferred.
  • Experience with floating and mounted rodent sections required. Large animal experience is preferred.
  • Light and confocal microscopy experience.
  • Proficiency with histological image analysis and statistical analysis, experience with image quantification tools.

The level of this position will be based on the final candidate's qualifications.

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

Novartis Gene Therapies Benefit Summary:

Annual bonus, long term incentive, health insurance, paid vacation/holidays, potential flexible working arrangements (based on role) and an employee recognition program are available for this position, among many other benefits provided to employees of Novartis Gene Therapies.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Novartis Gene Therapies is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.