Scientist, Protein Biochemistry

Tarrytown, New York, United States of America
Jul 18, 2021
Required Education
Bachelors Degree
Position Type
Full time
Regeneron's Protein Biochemistry Group, in Tarrytown NY, is seeing a biophysical chemist with a strong background in computational biophysics. We perform extended biophysical characterization of all therapeutics for our pipeline, is seeking a biophysical chemist. In this role, you will provide in-depth biophysical and biochemical characterization of protein-based therapeutics and novel modalities to support programs in late stage research through IND.

A Typical Day In the Role of Scientist in our Protein Biochemistry Group May Include the Following:
• Independently craft and conduct computational and wet protein biophysical and biochemical experiments; analyzes data to elucidate quality attributes of protein-based candidates and/or products.
• Provide computational and experimental biophysical support for both upstream and downstream functional areas; help solve problems in real-time.
• Take a leading role in efforts to characterize various modalities within specified timelines and works optimally in matrix-based team within protein biochemistry.
• Meticulously document experiments, results and findings in electronic laboratory notebook; presents work at group and department meetings; contributes to drafting of analytical characterization reports, regulatory submission sections, and peer-reviewed articles for publication.
• Serve as a team representative in drug candidate-specific development team meetings, and share knowledge and expertise of biophysical chemistry at cross-function team meetings.

This Role Might Be For You If:
• You possess the desire and ability to work in a team environment.
• You are passionate about Science and innovation with a strong commitment to continual improvement and teamwork
• You enjoy an even split of time between computational and experimental protein biophysical chemistry.

This Role Requires a PhD in biophysical chemistry, biochemistry, chemical engineering or equivalent with 2-4 years post-doctoral training or combined with industry experience in analytical characterization of proteins. Prior experience in or collaboration with the biopharmaceutical industry is preferred. Knowledge of and demonstrated experience in size-based methods (Analytical Ultracentrifugation, Static/Dynamic Light Scattering, and liquid chromatography).
Demonstrated experience in conducting all-atom and coarse-grained simulations of proteins or related biological macromolecules using molecular dynamics engines such as GROMACS, NAMD, or DESMOND is essential. Experience with Free-energy Perturbation, Metadynamics, and related advanced sampling methodologies are a plus.
The candidate must demonstrate broad, in-depth knowledge of colloidal and macromolecular physics and biophysics and how this applies to proteins, polymers, viruses, particles and nucleic acids.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.