Senior Research Associate/Associate Scientist I/II (mr)

Redwood City, CA
Jul 17, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Adverum is looking for a Senior Research Associate/Associate Scientist I/II to join our team in our Redwood City office. This individual will support the Assay Development team through quantitative assay development and performance in a variety of formats in support of product release as well as pharmacokinetics and pharmacodynamics. 

What you'll do:
  • Work with senior scientific personnel to design, develop, qualify or validate, troubleshoot, and transfer ligand-binding assays, enzyme activity assays, immunogenicity assays, and product characterization assays to internal and external scientists and support the development of cell-based assays 
  • Participate in decisions on experimental approaches and interpretation of data 
  • Work collaboratively with different research and development departments to evaluate and implement new assay formats and/or technologies
  • Transfer of assays to and oversee work at Contract Research Organizations and with the QC group 
  • Maintain current knowledge of regulatory requirements for bioanalytical and product characterization assays 
  • Write test procedures, protocols, and technical reports, qualification plans and reports.
  • Present project status updates in internal forums 
  • May perform some internal sample analysis needed in support of product characterization and preclinical studies 
  • Maintain excellent documentation of laboratory activities 
  • Perform routine lab maintenance 
  • Other responsibilities may be assigned as needed

About you:
  • Minimum of a biological science bachelor’s degree with 8+ years’ experience in a biotech company, or a master’s degree with 5-6 years’ experience, or an equivalent combination of education and experience 
  • Experience in assay development is required 
  • Expertise in a variety of laboratory techniques involving protein analysis including analyte quantitation such as ELISA, MSD, and similar, Western blotting, and immunogenicity assays, potency assays is required.  Experience with sterile tissue culture techniques (transfection, transduction, maintaining cell lines)
  • Experience with analysis of proteins in mammalian tissues is preferred. 
  • Experience in the qualification/validation of quantitative assays and FDA requirements for these is desired. 
  • Broad knowledge of protein assay methods and biochemistry with application to gene therapy is strongly desired. Ability to read and extract information from published literature and internal reports is required. 
  • Background in the area of retinal or genetic diseases is desired, with an understanding of AAV biology a plus 
  • Must be a self-starter, proactive, co-operative, and proficient at working both independently and in a small team environment 
  • Proven initiative and demonstrated accountability in a fast-paced environment with high degree of flexibility. 
  • Detail oriented and with time management skills 
  • Excellent verbal and written communication skills. Experience in presenting data through written reports and oral presentation. 
  • Publication in a peer-reviewed journal or having presented at a conference is desired 
  • Proficiency with SoftMaxPro, GraphPad Prism, and other common analytical software desired 
  • Proficient with MS Office and other common office software 

About Us
Adverum is a clinical-stage gene therapy company targeting unmet medical needs in ophthalmology and rare diseases. Adverum develops gene therapy product candidates designed to provide durable efficacy by inducing sustained expression of a therapeutic protein. Adverum’s core capabilities include clinical development, novel vector discovery and in-house manufacturing expertise, specifically in scalable process development, assay development, and current Good Manufacturing Practices quality control.

At Adverum, Inclusion and Diversity are at our core. We believe in the power of being your authentic self.  We strive to create the space which allows for everyone in our Adverum Community to not only feel safe but encouraged to speak, learn from each other, grow in their professions and be the very best versions of themselves no matter what their age, ethnic background, gender, origin, religion or sexual orientation