Principal Scientist/Associate Director, Translational Medicine

San Francisco Bay Area
Jul 16, 2021
Biotech Bay
Required Education
Position Type
Full time

Zai Laboratories seeks an innovative leader to drive our translational biology efforts in the areas of cell cycle (CC) and DNA damage response (DDR).  The successful candidate will devise and execute translational strategies to guide indication selection and patient stratification for Zai's late-stage pre-clinical and clinical pipeline in the areas of CC and DDR. This position is located in Menlo Park, CA and reports to the Head of Discovery Biology and Translational Medicine.


- Drive translational biology efforts and design and execute biomarker strategies for therapeutic programs targeting the CC and DDR pathways

- Lead translational biology for CC and DDR therapeutics on multi-disciplinary teams for programs in late-stage research (LSR) and in clinical development

- Collaborate with biologists, immunologists, chemists, statisticians, and computational biologists to develop strategies for indication prioritization and patient stratification

- Discovery and validate pharmacodynamic and predictive biomarkers for CC and DDR programs in LSR and in the clinic

- Effectively communicate findings at internal and external meetings through presentations and scientific publications


- Ph.D. in cellular, molecular biology, or a related field, and 5+ years of experience ideally in an industry setting OR

- MS in cellular, molecular biology, or a related field and 8+ years of experience ideally in an industry setting

- Extensive experience in the discovery and/or development of therapeutics targeting the CC and DDR pathways, as evidenced by a track records of success in advancing drug discovery programs into the clinic

- Translational experience in the discovery and implementation of pharmacodynamic and predictive biomarkers using pre-clinical models, both in vitro and in vivo, and in clinical trials

- Strong track record of multi-tasking and systematically evaluating and prioritizing multiple hypotheses both independently and collaboratively

- Excellent problem-solving and strong communication, data presentation, and visualization skills

- Strong record of scientific accomplishments, as evidenced by publications in top tier journals, patents, and conference presentations

If you are interested in this position, please send an email with your resume.