Scientist, Payload Enginering

Emeryville, CA
Jul 15, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
4D Molecular Therapeutics, Inc. (“4DMT”) is a clinical-stage gene therapy company pioneering the development of product candidates using targeted and evolved AAV vectors. 4DMT seeks to unlock the full potential of gene therapy using its platform, Therapeutic Vector Evolution, which combines the power of directed evolution with approximately one billion synthetic capsid sequences to invent evolved vectors for use in targeted gene therapy products. The company is initially focused in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT targeted and evolved vectors are invented with the goal of being delivered through clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in target tissues efficiently, having reduced immunogenicity and, where relevant, having resistance to pre-existing antibodies. 4DMT is currently conducting three clinical trials: 4D-125 is in a Phase 1/2 clinical trial for XLRP, 4D-110 is in a Phase 1 clinical trial for choroideremia and 4D-310 is in a Phase 1/2 clinical trial for Fabry disease.

4DMT is focused on attracting and retaining the best people in the industry who identify with our mission and innovative results-driven approach. We offer an inspiring and collaborative environment that encourages individual contributions, recognizes performance in multiple ways, offers competitive salary and benefits, and provides challenging opportunities for career development.  4D Molecular Therapeutics is located in Emeryville, CA.

This role supports the Payload Engineering group within the Vector and Product Development Unit. They will report to a Scientist within the Payload team and work in collaboration with their manager and other research associates and scientists on the team and within the greater V&P unit to design, construct and validate function of AAV cassettes for various disease indications.  They will play an integral part in building novel therapeutics for a range of disease targets utilizing a variety of intervention strategies including, gene replacement, siRNA and antibody production.
  • Lab Activities: 70%
  • Supports the design and construction of AAV genomic DNA cassettes through molecular DNA cloning techniques
  • Amplify and purify DNA plasmids
  • Development of assays to test expression and function of constructed plasmids
  • Communication and Scientific Administrative Tasks: 30%
  • Contribute scientific ideas and knowledge in departmental and cross-functional team meetings
  • Effectively present findings at departmental and cross-functional team meetings
  • Engage in study design for various programs
  • Help compile and write data sections for IND preclinical pharmacology reports
  • Communicate effectively with management to achieve departmental goals
  • Other duties as assigned, nothing in this job description restricts management’s right to assign or reassign duties and responsibilities to this job at any time

  • Ph.D. in relevant field, Cell and Molecular Biology or Master’s Degree in relevant field – 2+ years of relevant experience
  • Experience:
  • 4+ years of molecular cloning experience within the Biotech or similar industry
  • 2+ years basic cell culture experience
  • Skills:
  • Molecular DNA cloning
  • PCR and other DNA amplification and isolation techniques
  • Cell Culture
  • Transformation/Transfection/Transduction
  • Gel electrophoresis and DNA purification
  • ELISA/Western blot analysis
  • Sequencing analysis and plasmid map design
  • Applies technical and functional knowledge to design experiments / projects that contribute to the departmental goals
  • Guides the successful completion of projects in collaboration with team members
  • Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought
  • Exercises judgment within broadly defined practices and policies in selecting methods, techniques, and evaluation criteria for obtaining results
  • Applies scientific/technical knowledge gained at conferences or through literature to advance project work
  • Acts as a resource for colleagues with less experience; may lead small projects with manageable risks and resource requirements
  • Contributes to and may author scientific/technical documents (posters, publications, regulatory documents, patent applications, technical reports)
  • Effective communication and collaboration within team and across departments
  • Physical Requirements of the Role:  
  • Lifting no more than 20 lbs for lab organization and storage
  • During COVID-19 will this person need to be in a lab 5 days a week and adhere to 4DMT Covid protocols and policy

4DMT provides equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, gender, sexual orientation, national origin, age, disability, genetic information, marital status, status as a covered veteran and any other category protected under applicable federal, state, provincial and local laws.

Equal Opportunity Employer/Protected Veterans/Individuals with Disabilities