Senior Scientist - In Vivo Pharmacology

Location
Cambridge
Posted
Jul 15, 2021
Ref
5270030002
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

Sana Biotechnology is looking to expand our team with hard-working individuals who believe in the potential of cell and gene-therapies as engineered medicines, have the vision to innovate, and the determination to execute upon that vision. We are looking for a Senior/Principal Scientist to join the In Vivo Pharmacology group. This individual will work closely with colleagues on projects in a variety of therapeutic areas in a highly dynamic and cross-functional environment. They will be responsible for developing and executing non-clinical in vivo studies of drug candidates to support ongoing research and early development activities. The successful candidate will have demonstrated a strong understanding of T cell biology, excellent communication skills, technical proficiency, scientific rigor, independent thought, the ability to handle several multi-faceted studies at once and a team-oriented mentality.

DUTIES AND RESPONSIBILITIES
  • Effectively design, develop, manage, and track all aspects of non-clinical in vivo studies
  • Design and develop flow cytometry multicolor panel design, reagent assessment, staining protocols, instrument operation, cell sorting, data acquisition, and data analysis
  • Expertise in designing mouse studies, developing ex vivo cell-based biological assays and expertise working with a diversity of mammalian cell types including cell lines and primary cells
  • Design and execute preclinical in vivo studies to understand the pharmacokinetics (PK) and distribution of drug candidates
  • Calculate and coordinate test article needs, coordinate across multiple departments for study support such as ex vivo analyses (e.g. in vitro sciences and pathology) and procedural aid
  • Lead, monitor and execute multiple s studies in collaboration with team members ensuring proper dosing, sampling, harvesting and implementation of study activities and generating monitoring reports for internal and QA review
  • Analyze and generate study reports including management of review and interpretation by partner scientists; finalize reports with close collaboration with senior leadership members and cross-functional team members (I.e. statisticians, in vitro sciences PK/PD)
  • Formally present study design and data interpretation at internal group, department or Project Team meetings and where appropriate present externally at relevant scientific meetings
  • Write or review study protocols, coordinating cross-functional review and agreements
  • Work fluidly with Research Project Team leads to update timelines and manage expectations and deliverables.
  • Provide mentorship and guidance to junior associates
  • Demonstrate Sana's core values and the attributes that support these core values (Lead from every seat, Thrive as a team, Make it happen)

QUALIFICATIONS

Basic Qualifications
  • PhD or equivalent in immunology, molecular biology or related field with 5+ years experience post-PhD
  • Demonstrated expertise in cellular immunology, molecular biology and flow cytometry
  • Hands-on experience handling, dosing, and performing tissue collections
  • Solid understanding of the 3R's and animal welfare regulations
  • Expertise in designing, executing and analyzing experiments and participating in scientific research strategies in collaboration with lead scientists (e.g. pharmacology, bioanalytical, toxicology, and pathology)
  • Must be detail-oriented, with ability to multi-task and work cross-functionally with team members and team environments.
  • Ability to organize, communicate and present program progress to key stakeholders from diverse backgrounds
  • Excellent interpersonal, organizational, and problem-solving skills required to manage multiple studies at different phases in parallel and track work and projects to meet timeline demands
  • Must be proficient with MS Office (Word, Excel, PowerPoint etc.) and Prism
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19

Preferred Qualifications
  • Hands-on experience developing and characterizing CAR-T cell products is preferred
  • Proficiency in assays interrogating T cell function, such as cellular activation, proliferation and functional assays (i.e. killing, proliferation) is highly preferred


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.