In Vivo Specialist, CNS

Location
Cambridge
Posted
Jul 15, 2021
Ref
5045129002
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

The In Vivo Specialist, CNS is responsible for the in vivo assessment of manufactured glial cells in Sana's Cambridge CNS lab. This individual will both manage and participate in the transplant and post-transplant evaluation operations of Sana's CNS Therapy lab, with direct oversight of at least one of its experimental programs. This position includes technically diverse bench and analytic work as well as the training of research staff in techniques and equipment use, across the CNS in vivo program.

The In Vivo Specialist, CNS will report on a direct basis to the Director, CNS Cell Biology, and work under the broader direction of the Head of CNS Therapy.

DUTIES AND RESPONSIBILITIES
  • Performing both neonatal and adult small animal surgeries and cell transplants
  • Neurohistological processing including tissue sectioning and immunohistochemistry of experimental brain tissues
  • Assuring the quality and integrity of all data collection and documentation
  • Microscopy and image analysis of processed samples
  • Coordinating, and in some cases conducting, behavioral analysis of animal subjects
  • Assisting with the management of experimental rodent colonies
  • Assuring compliance with all relevant lab safety and biosafety regulations
  • Formulating animal use procedures and experiment-specific protocols as required
  • Demonstrate Sana's core values and the attributes that support these core values (Lead from every seat, Thrive as a team, Make it happen)

QUALIFICATIONS

Basic Qualifications

The successful candidate is expected to have extensive hands-on expertise in stereotactic small animal surgery as well as neural cell transplantation and the downstream neurohistological analysis of transplanted animals, particularly quantitative histology. Candidates should also be familiar with concepts of transgenic mouse husbandry and identification of suitable mouse models. The successful candidate will have sufficient personal expertise to teach as well as troubleshoot these techniques. In addition, the candidate is expected to be able to contribute towards the maintenance of both the histology and behavior lab environments, including day to day operations and personnel coordination, as well as assuring the quality of data collection.
  • BA/MA in neuroscience or cell biology, chemistry or biotechnology, or a related field
  • 5+ years of post-college academic or industry experience in neural and glial cell biology
  • Significant expertise in and understanding of rodent neuroanatomy
  • Significant experience with immunochemistry, microscopy and digital image analysis
  • Experience in working with preclinical models.
  • Expertise in mouse colony management and genotyping
  • Expertise in methods of mouse behavioral assessment
  • Excellent interpersonal, communicative and problem-solving skills
  • Proficiency with MS Office, and with standard programs for statistical analysis (e.g., GraphPad Prism) and slide imaging and quantitative histology (e.g., StereoInvestigator)
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19

Preferred Qualifications
  • Background in neuroscience/neurobiology
  • Significant experience in rodent neurosurgery
  • Experience in basic cell culture practices
  • Experience in tissue preparation and histology

WORKING CONDITIONS

Occasional scheduled weekend and holiday coverage may be required, on rotation with technical staff, in order to ensure project performance at defined time points.

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.