Senior/Principal Scientist, DMPK

BridgeBio finds, develops, and delivers breakthrough medicines for genetic diseases. The company bridges remarkable advancements in genetic science with the entrepreneurial engine required to rapidly create lifesaving medicines for patients with unmet needs. Founded in 2015 by a team of industry veterans, the company has built a portfolio of 20 transformative drugs ranging from pre-clinical to late-stage development in multiple therapeutic areas including genetic dermatology, oncology, cardiology, neurology, endocrinology, renal disease, and ophthalmology. The company’s focus on scientific excellence and rapid execution aims to translate today’s discoveries into tomorrow’s medicines. We have offices in San Francisco, Palo Alto, Boston, New York, and Raleigh, with small satellites in other parts of the country. 

To learn more, visit us at https://bridgebio.com

Who You Are:

This is an exciting opportunity for a highly motivated and independent thinker to join a group of investigators developing novel small molecule cancer therapeutics.

This successful candidate will be a results-driven scientist with a keen understanding of the drug discovery process. This individual will lead DMPK efforts as part of a group of cancer biologists charged with targeting validation and enabling optimization/selection of development candidates for our current leading and new oncology research programs. We are looking for a talented and enthusiastic individual who thrives in a collaborative, fast-paced, and growing environment.

Responsibilities:

• Serve as DMPK subject matter expert for nonclinical development
• Collaborate with chemistry and pharmacology to guide DMPK lead-optimization and elucidate PK/PD relationships
• Manage CROs in designing and executing in vitro/in vivo ADME/PK studies
• Communicate DMPK results leading to critical go, no-go decisions
• Write, review, and edit preclinical DMPK reports of regulatory submissions

Education, Experience & Skills Requirements:

• Ph.D. in Pharmacokinetics, Pharmacology, Pharmaceutics, or other relevant fields with 3+ years of hands-on laboratory experience contributing DMPK data to project teams
• or M.S. in Pharmacokinetics, Pharmacology, Pharmaceutics, or other relevant areas with 6+ years of hands-on laboratory experience contributing DMPK data to project teams
• or B.S. in Pharmacokinetics, Pharmacology, Pharmaceutics, or other relevant areas with 10+ years of hands-on laboratory experience contributing DMPK data to project teams
• Strong knowledge of ADME/PK concepts, modeling, and bioanalytical principles
• Proficient in standard M.S. software (Word, Excel, and PowerPoint) and experience using pharmacokinetic software (e.g., WinNonlin)
• Strong communication skills (verbal and written) and presentation skills required
• Excellent interpersonal skills and the ability to represent DMPK in a team environment are essential
• The title will be commensurate to the candidate’s education and experience

What We Offer:

• Patient Days, where we are fortunate enough to learn more about the lives we are looking to impact and a real exchange of ideas as to how we can improve our efforts
• A culture inspired by our values: put patients first; think independently, be radically transparent; every minute counts, and let the science speak
• Learning and development training to help employees be the best version of themselves
• Collaborative business environment
• Excellent compensation package (Base, Performance Bonus, Stock, RSU programs)
• Excellent benefits package
• Flexible PTO
• With office locations in San Francisco, Boston, New York, and Raleigh, there are ample cross-collaboration opportunities with other BridgeBio Pharma programs
• A fast-paced, data-driven, work environment with world-class R&D minds and capabilities
• Work with the most productive groups of R&D operators in the industry
• Partnerships with leading institutions
• A platform for meaningful scientific contributions to shine
• Commitment to Diversity & Inclusion – with initiatives like Women at Bridge, we are committed to fostering an inclusive environment where every person feels respected for who they are, empowered to contribute, inspired to lead, and supported in their efforts to do so

We will not accept unsolicited resumes from agencies. Please do not send agency resumes to our website or BridgeBio and affiliating employees.