Sr. Scientist, Cell Biology

Location
Hamilton and Toronto, Ontario
Posted
Jul 13, 2021
Required Education
Doctorate/PHD/MD
Position Type
Full time

JOB SCOPE:

Triumvira Immunologics is seeking an energetic and accomplished scientist with 3+ postdoctoral experience in industry or academia and broad experience in immunology or related discipline. Specific expertise in T cell biology and immune oncology, including the tumor microenvironment, is required.  The candidate will be part of the R&D pharmacology team focused on the development of novel, genetically engineered T cell therapeutics to combat cancer and other indications.  The successful candidate will lead the development of next generation imagining approaches and 3D tissue models to functionally characterize engineered T cells in vitro and in vivo. Extensive experience with tissue culture, co-culture assays, 3D in vitro cultures, fluorescence and luminescence-based imaging, and real time microscopy are required. The candidate must have a strong publication record, strong oral and written communication skills and a proven ability to manage external collaborations. 


JOB DUTIES

• Lead the development of automated quantitative image analysis.

• Lead hands-on the execution of established co-culture assays to study drug product. 

• Lead hands-on the development of new in vitro assays to study drug product in co-culture assays such as 3D cultures (spheroids).

• Lead the development of multi-color IF of tissues or cells either in house or by interacting with CROs as required.

• Propose and design experiments to study drug product in immune/oncology relevant in vitro settings. 

• Provide support and training to other imaging equipment users. 

• Support the development of new imaging assays with CROs as required. 

• Manage CRO projects as required.

• Prepare comprehensive and concise data analysis in form of reports and presentations.

• Support the development and maintenance of relevant documentation (e.g. Imaging equipment SOPs)  

• Attend scientific conferences and provide feedback on current development sin the Immun/oncology field.

• Maintain imaging equipment.

• Ensure compliance with biosafety regulations.


EDUCATION

PhD, Immune Oncology, Immunology or a related field is required


WORK-RELATED SKILLS & EXPERIENCE

·     Extensive applied microscopy experience

·     Proven track record of successfully designing imaging experiments (i.e. time laps, multi color IF).

·     Extensive experience designing automated image analysis using various software such as ImageJ.

·     Extensive experience preparing samples for immunofluorescence.

·     Extensive tissue culture experience.

·     Extensive experience preparing co-culture assays.

·     Experience interpreting histology slides.

·     Microsoft office (Word, Excel, PowerPoint, Outlook)