Principal Scientist, RNA Technologies

Cambridge, MA, United States
Jul 13, 2021
Required Education
Bachelors Degree
Position Type
Full time
Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia:

Intellia is seeking a highly skilled and motivated RNA Scientist to join our growing team. In this role, you will discover and develop technologies for in vitro transcribed mRNA production, purification and optimization for applications in the CRISPR/Cas9 gene editing system. In addition, you will be working closely with the guide RNA team to design and chemically modify guide RNA to improved potency and develop bio-chemical assays to understand the interaction of modified guide RNA with protein. Other responsibilities include:

  • Discover and develop new bench-scale, scalable processes for generating mRNA, and assist in transferring protocols to production group and/or CROs
  • Explore and develop new techniques for generating higher potency mRNA through avenues such as increasing stability, expression efficiency, etc.
  • Assist in analytical development for in vitro transcribed mRNA to reach the above-described aims
  • Develop biochemical assays for mRNA
  • Design, implement, and troubleshoot experiments, both independently and in collaboration with colleagues, to reach desired goals
  • Communicate research and development findings with internal and external partners
  • Understanding of nucleic acid modifications
  • Work closely with guide RNA team in evaluating new chemical modifications and develop biochemical assays
  • Develop RNA technologies pertaining to therapeutics and understanding the biological consequences of synthetic modified RNAs.

About You:

We are looking for a collaborative and detailed - oriented Scientist to join our team. Our ideal candidate will have f amiliarity with nucleic acid, particularly RNA, chemistry, structure, and manipulation . If you bring a Ph.D. in Chemistry, Biochemistry, Biochemical or Chemical engineering or related discipline with at least 4-6 years of post-PhD experience, we encourage you to apply! Other requirements include:

  • Experience in biomolecule separations and method development using FPLC, HPLC, and/or UPLC.
  • Experience with assay development for nucleic acids (e.g. electrophoresis, enzyme reactions, and/or PCR ) .
  • Experience in developing bio-chemical assays for mechanistic understanding .

Meet your future team:

Chemistry and Delivery Sciences team are a fun, energetic, and passionate group of individuals whose mission is to develop the chemical building blocks that enable curative therapies. You will report directly to the Senior Director, Head of Chemistry and Delivery Sciences team. This hiring manager co-leads Intellia's Platform Delivery Project to identify next generation, more efficacious drug candidates/delivery system for future clinical programs. Given the breadth of work on this team, the candidate will have the opportunity to explore a wide range of areas within the Chemistry and Delivery sciences spaces that support Intellia's gene editing pipeline. This position will have two direct reports.

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, we strongly prefer the candidate to be currently local to Cambridge MA, or open to relocating. While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for growth of scientists interested in a career in RNA-biotech. If you join our team, you can expect to join a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patient's lives.


EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.