AbbVie

Senior Scientist II

Employer
AbbVie
Location
Cambridge, Massachusetts
Posted
Jul 13, 2021
Ref
2111402
Required Education
Bachelors Degree
Position Type
Full time
About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on Twitter, Facebook, Instagram, YouTube and LinkedIn.

 

About AbbVie
AbbVie’s mission is to discover and deliver innovative medicines that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas: immunology, oncology, neuroscience, eye care, virology, women’s health and gastroenterology, in addition to products and services across its Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com. Follow @abbvie on TwitterFacebookInstagramYouTube and LinkedIn.

AbbVie’s Immunology R&D organization is expanding its early discovery team at the Cambridge Research Center in Cambridge, MA. We are seeking a highly motivated Senior Scientist to join the Translational and Transformational Immunology Discovery team.  This scientist will specifically support the development of preclinical in vitro models for Th2-type immune diseases such as atopic dermatitis, eosinophilic esophagitis, and prurigo nodularis. Our team is looking for a candidate with existing academic or industry experience in working with human innate effector cells of allergic Th2-type reactions.  Candidates will be expected to be well-versed in mast cell, basophil, and eosinophil biology and to understand the role of these cell types in driving Th2-type immune diseases. Industry experience is not mandatory but having in vitro pharmacology and drug discovery experience is a plus.

Key responsibilities include:

  • Develop in vitro models of innate immune cells that mimic the pathophysiology of atopic dermatitis, EoE, and other Th2-type immune diseases.
  • Work collaboratively and independently to develop the in vivo strategies for target validation and execute study designs.
  • Incorporate relevant external sources (literature, patents, conferences) and state-of-the art technologies and theories to guide novel in vitro model builds.
  • Process and analyze ex-vivo human and animal tissues for disease-relevant endpoints.  Candidates with knowledge of the following techniques will receive extra consideration: flow cytometry, PCR/gene analysis, protein/cytokine measures via ELISA/MSD, and other skin-related functional endpoints.
  • Contribute to the design and analysis of in vivo models of Th2-type diseases including designing and contributing to mechanism-of-action (MOA) studies. Experience in conducting efficacy testing of drug candidate molecules (large and small) is preferred.
  • An excellent understanding of IgE-mediated immune responses in humans and rodents is essential. The candidates should be experienced in in vitro culture techniques and isolation methods for primary human innate immune cells.
  • Interpret findings and effectively present scientific data, concepts, and recommendations to various internal audiences.  May attend or present at external conferences.
  • Author and review technical reports, protocols, manuscripts, and other key documents.
  • Excellent communication skills
  • Work in AbbVie’s matrix environment and support activities in the Th2 disease area as needed, which may include acting as the functional representative for pipeline projects and leading new target proposals.

Qualifications

Qualifications:

  • PhD in Molecular biology or Immunology or other biological sciences with typically 0-4+ years post-doctoral experience; or Master Degree or equivalent with typically 8-10+ years of experience; or Bachelor Degree or equivalent with typically 10-12+ years of experience

Key AbbVie Competencies: 

  • Builds strong relationships with peers and cross functionally with partners outside of the team to enable high performance.
  • Learns fast, grasps the “essence” and can change course quickly where indicated.
  • Raises the bar and is never satisfied with the status quo.
  • Creates a learning environment, open to suggestions and experimentation for improvement.
  • Embraces the ideas of others and nurtures innovation to make possibilities real.

 

 

Posting Grade: 17 / 18

Job Grades are determined by the country in which the payroll is based.

Location:  Cambridge, MA


Significant Work Activities
Continuous sitting for prolonged periods (more than 2 consecutive hours in an 8 hour day)
Travel
Yes, 50 % of the Time
Job Type
Experienced
Schedule
Full-time
Job Level Code
M
Equal Employment Opportunity
At AbbVie, we value bringing together individuals from diverse backgrounds to develop new and innovative solutions for patients. As an equal opportunity employer we do not discriminate on the basis of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information gender identity or expression, sexual orientation, marital status, protected veteran status, or any other legally protected characteristic.