Senior Scientist, Analytical Chemistry

Location
South San Francisco, CA, United States
Posted
Jul 10, 2021
Ref
5321950002
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

Sana Biotechnology has an exciting opportunity for a Scientist to Senior Scientist, Analytical Chemistry to advance Sana's novel gene and cell therapy programs. The scientist will develop physiochemical methods for the characterization of novel viral vectors, gene editing reagents and residual process related impurities. This role provides the opportunity to work closely with Technical Operations colleagues in upstream, downstream and pharmaceutical development with the goal of developing robust biomanufacturing processes and formulations and contributing to the deeper understanding of our products and their impurity profiles. The candidate will represent AD on internal, cross functional teams and with external collaborators. The candidate will demonstrate their innovation and resourcefulness by leveraging internal capabilities and external collaborators to bring cutting edge technologies to Sana.

DUTIES AND RESPONSIBILITIES
  • Develop robust analytical methods for characterizing intermediates, drug substances/products and measuring residual impurities including proteins, nucleic acids, viral vectors, particulates and small molecules.
  • Initiate and lead efforts to bring new analytical technologies on site through utilization of internal resources/expertise and collaboration with external vendors.
  • Conceive, drive and execute analytical development initiatives that address challenges, enable bioprocess development and provide a deeper understanding of our products and processes.
  • Represent analytical development on external and internal teams.
  • Serve as a subject matter expert for one or more analytical techniques.
  • Overcome obstacles (time constraints, material limitations and instrumental capabilities) through creative solutions, collaboration and problem solving.
  • Demonstrate Sana's core values and the attributes that support these core values (Lead from every seat, Thrive as a team, Make it happen)

QUALIFICATIONS

Basic Qualifications
  • PhD in Analytical Chemistry, Biochemistry or equivalent life science with 2+ years industry experience. BA or MS plus 7+ years or equivalent combination of education and work experience.
  • Demonstrated ability to design, execute, and analyze complex experiments with statistical analysis and scientific rigor.
  • Experience with different modes of chromatography and electrophoresis for quantitative analysis of various analytes (proteins, nucleic acids, viral vectors, small molecules).
  • Experience with different types of spectroscopy (UV, FTIR, fluorescence) and plate-based assays.
  • Experience with biophysical methods for counting particles and measuring their size distribution and
  • Hands on experience with biological Mass Spectrometry.
  • Familiarity with immunochemical assays (ELISA, western blots, etc.).
  • Excellent verbal and written communicate skills for technical and non-technical audiences
  • Detail oriented, self-motivated, independent, adaptable, and able to prioritize and manage several projects concurrently.
  • Demonstrated ability to work independently and as a valued colleague in cross-functional teams.
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.

Preferred Qualifications
  • Analytical development experience at a cell and gene therapy company
  • Experienced with method validation and transfer to QC.
  • Contributed to regulatory filings by authoring sections and generating data and source documents.
  • Managed activities at CMO's and contract testing labs.
  • Familiarity with relevant guidance documents and GMP principles.
  • Demonstrated leadership for effective project management and supervisory aptitude / experience to enable potential expansion of responsibility to include direct reports.


To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.