Scientist, Fibrosis

Location
South San Francisco, CA
Posted
Jul 09, 2021
Ref
138
Hotbed
Biotech Bay
Required Education
Doctorate/PHD/MD
Position Type
Full time

The Opportunity

The heart of Insitro's strategy is the development of novel, cutting edge methods in machine learning and high-throughput biology that address key bottlenecks in the drug development pipeline. We are seeking an exceptional scientist to join our fibrosis team. This position offers a unique opportunity to drive research efforts to discover and develop novel therapies for the treatment of chronic fibrotic diseases including NASH. In this role, you will support and lead projects focused on identifying and validating disease phenotypes and therapeutic targets. In collaboration with the Functional Genomics, Disease Modeling, Process Engineering, and DS/ML groups, you will participate in cross-functional drug discovery teams from project concept to IND submission. There will be ample opportunity for career development and growth in this fast-paced environment.


Your primary duties will be to: 

  • Design and conduct studies required to identify and advance novel candidates that have potential to impact fibrotic diseases. 
  • Conceive and implement novel cellular assays in translatable model systems to persecute fibrotic pathway and target validation. 
  • Work in a cross-functional matrix organization with fellow biologists, chemists, data scientists and engineers to generate data sets to predict disease specific markers and assays. 
  • Design and execute genetic and chemical screens, conduct detailed data analyses and present these to project teams and senior management.


You will be joining a biotech startup that has long-term stability due to significant funding, providing many opportunities for meaningful impact. You will work closely with a very talented team, learn a broad range of skills, and help shape insitro’s culture, strategic direction, and outcomes. Join us, and help make a difference to patients!


About You

  • PhD in life sciences or equivalent practical experience in fibrotic indications and biology. 
  • Strong track record of scientific accomplishments, demonstrated by peer-reviewed scientific publications in high impact journals. 
  • Preference will be given to candidates with experience in identifying and validating molecular targets that contribute to the pathophysiology of fibrosis (including NASH).
  • Strong experience with mammalian cell culture and familiarity with primary or iPSC-derived cell culture is preferred.
  • Experience in the use of molecular techniques to evaluate signalling networks and gene expression analysis.  
  • A strong scientific track record in assay development, optimization and troubleshooting 
  • Familiarity with high throughput technologies for small molecule profiling.
  • Demonstrated ability to work cross functionally, including with data scientists,  computational biologists, and process engineers.
  • Other criteria will include: excellent teamwork, communication, time management and organization skills
  • Passion for making a difference in the world


Benefits at insitro

  • Excellent medical, dental, and vision coverage
  • Open vacation policy
  • Team lunches (catered daily)
  • Complementary onsite barista and snacks
  • Commuter benefits
  • Paid parental leave


About insitro

insitro is a drug discovery and development company using machine learning and data generation at scale to transform the way that drugs are discovered and delivered to patients. We rely on human genetic cohorts, human-derived cellular disease models, and high-throughput biology and chemistry to identify coherent patient segments, actionable therapeutic targets, and new or existing chemical matter. The goal is to deliver predictive insights to improve the probability of success and reduce the number of costly dead ends along the R&D journey. The company has established collaborations with Gilead in NASH and Bristol Myers Squibb in ALS and is building a pipeline of wholly owned and partnered medicines leveraging its unique insights on patient biomarkers, targets, and molecules. insitro is located in South San Francisco, CA and has raised over $600M from top tech, biotech, and crossover investors since formation in 2018. For more information on insitro, please visit the company’s website at www.insitro.com.