Scientist, Lipid Nanoparticle Technology (LNP)

Location
Tarrytown, New York, United States of America
Posted
Jul 09, 2021
Ref
24636BR
Required Education
Bachelors Degree
Position Type
Full time
Regeneron's R&D Chemistry group is looking for a Scientist, Liquid Nanoparticle Development. In this role, you contribute to the advancement of new platform technologies, specifically, the innovation and optimization of the synthesis of lipids, lipid conjugates, and small molecules. You will also improve the purification, construction of these components into vessels to carry cargo, as well the purification and characterization of these sophisticated LNPs and individual components. In this role you will be given the opportunity to take part in independent research aimed at crafting vessels that can be advised to specific tissues.

A Typical Day in the Role of Scientist, LNP Might Look Like:
• Contribute to scientific efforts sought at the synthesis, purification, characterization, and formulation of diverse sophisticated bioconjugates that target LNPs to tissues.
• Execute the preparation and formulation of bioconjugates by applying established methodologies as well as developing new techniques.
• Apply and develop methods to characterize and analyze complex bioconjugates in the context of cargo containing LNPs.
• Prioritize and perform work independently, be self-motivated and capable of working in a multi-disciplinary environment.
• Participation in CRO activities, including design and project coordination.

This Role Might Be For You If:
• You are able to handle multiple projects at one time
• You are flexible and science-focused
• You have strong time management skills
This role requires a Ph.D. in synthetic organic chemistry or equivalent with demonstrated ability in a discovery setting. Experience includes modern organic synthesis, especially as applied to orthogonal bioconjugation chemistry, chromatography and analytical techniques including HPLC, MS, LC/MS and NMR preferred. Hands on experience with conjugation, purification and characterization of conjugates, and experience using analytical techniques/instruments, including chromatographic techniques such as HIC (Hydrophobic Interaction Chromatography) and RP (Reverse Phase) and normal phase chromatography, SEC, SDS-PAGE, UV-Vis, mass spectroscopy, and NMR a plus. Experience in the synthesis and evaluation of nucleic acid conjugates, antibody or peptide conjugates, and attachment chemistries is a plus. Expertise in purification and analytical techniques for LNPs a plus. Effective written and verbal communication skills with scientists in multiple disciplines.

Experience with the following additional skills and experience is a plus:
• Solid-phase oligonucleotide synthesis
• On or off bead oligo functional group conversion chemistries
• Oligonucleotide/oligonucleoside chemistry
• Large scale LNP conjugation and characterization to support pilot toxicology studies
• Protein engineering and expression in bacterial and eukaryotic systemsDoes this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.