Senior Associate Scientist, Oligonucleotide Process Development

Cambridge, MA, United States
Jul 08, 2021
Required Education
Bachelors Degree
Position Type
Full time
Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How You Will Achieve More with Intellia:

We are excited to welcome this new member to our growing team and company. This is both a strategic and hands-on role. If you are a strong and independent problem-solver, agile, detail-oriented with a strong technical background in synthetic oligonucleotides, and enjoy working in cross-functional teams, this is the role for you! As a Senior Associate Scientist, you will work on various activities including:
  • Assist setup of new oligonucleotide process development laboratory and supply chain.
  • Support design and execute solid phase oligonucleotide synthesis to produce oligonucleotides at bench scale. Analyze effectiveness of the synthesis (monitoring, in-process tests) and identify opportunities for improvements with the team.
  • Adopt conditions from external manufacturers and internal research for feasibility assessments. Work cross functionally with representatives of chemistry and analytical groups
  • Develop and test the applicability of PD modules for process evaluation of new sequences and establish/standardize workflow.
  • Test and optimize downstream oligonucleotide processing including chromatographic purification methods
  • Act as technical resource and author/review technical documentation such as SOPs, method documents, training documents, batch records and reports.

This is a unique role that will provide you with opportunities to impact ex vivo and in vivo applications by:
  • Develop, establish and evaluate processes for solid-phase synthesis and purification of modified and challenging oligonucleotide sequences for the CRISPR/Cas9 system.
  • Collaborate with Intellia's cross-functional platform development team and build the bases to define and optimize the manufacturing processes for the company's development pipeline, which may include transfer to external manufacturing organizations.

What you will bring to the table:
  • BS or MS in Chemistry, Biochemistry, Biotechnology or related field with 5 or more years of experience in an industrial setting with hands-on experience with solid-phase oligonucleotide synthesis and competency in operation of lab-scale oligonucleotide synthesizers
  • Experience with chromatographic purification of oligonucleotides (MPLC and HPLC, e.g. IEX, IP-RP) as well as general analytical techniques used for the analysis of DNA/RNA oligonucleotides (UV/fluorescence spectroscopy, mass spectrometry, sequencing applications)

Meet Your Future Team:

The Small Molecule Process Sciences Team (oligonucleotides and lipids) is a highly motivated and lively group, with an innate curiosity to learn. You will report to the Associate Director, Nucleic Acid Therapeutics Development and Manufacturing. This team leads various important elements of the Technical Operations (CMC) department, including sgRNA and lipid manufacturing/process development and interfaces via project teams with analytical development, mRNA and lipid nanoparticle manufacturing, quality, chemistry, and platform development. While a growing team of currently two team members, you will work closely with the larger NTDM team, made up of 16 individuals.

Although Intellia currently is a partially virtual environment, the Human Resources team and Cultural Ambassadors have made it a priority to continue to foster a sense of community among the group. This includes virtual happy hours, team all hands, game nights, and more! You can expect to join a hardworking, collaborative environment and to work with dedicated and team-spirited group of people.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.