Senior Scientist, Gene Therapy

Location
San Diego, CA, US
Posted
Jul 08, 2021
Ref
6075
Hotbed
Biotech Beach
Required Education
Bachelors Degree
Position Type
Full time
Overview

INNOVATION, QUALITY, COLLABORATION, PERFORMANCE, COURAGE AND INTEGRITY

Novartis Institutes for Biomedical Research (NIBR) Biologics Center (NBC) builds the Novartis biologics pipeline in collaboration with NIBR Disease Areas and Platforms via a breadth of technologies for discovery of antibody, protein and gene therapy-based therapeutics. The Biotherapeutic Engineering and Gene Therapy (BEGT) group within NBC drives a diverse portfolio of modalities including therapeutic proteins, multi-specific antibodies, CAR-T, RNA therapeutics and rAAV. Through cell and viral engineering as well as innovative and rational protein design, the BEGT group is a global team that works collaboratively with disease area groups to broaden the use of biologics into therapeutic applications where conventional antibodies have limitations.

The Senior Scientist, Gene Therapy is part of the NBC/BEGT Next Generation AAV group and is responsible to lead and contribute to the development of innovative medicines for patients devastated by rare diseases in collaboration with partners across the global Novartis research and development network.

Responsibilities
  • Designs/develops experimental strategies and assays.
  • Supports in vitro cell-based and in vivolarge animal (e.g. nonhuman primate) studies to assess mechanisms regulating AAV delivery, efficacy and safety.
  • Leads, oversees and/or participate in next generation AAV projects across multiple Novartis sites to enable gene therapy platform advances and novel therapeutic capabilities in close collaboration with disease area leaders and global project teams.
  • Examines/analyzes data and prepare technical reports and protocols, adhering to the good research practices and quality culture across NIBR.
  • Contributes to maintaining a safe laboratory environment and quality work practices.
  • Other relates duties as assigned.

Qualifications
  • Bachelor's, in gene therapy, molecular biology, cell biology, biochemistry, bioengineering, or related scientific field with 8 years relevant experience or Master's with 6 or PHD with 4.
  • Demonstrated expertise in AAV genomics, ddPCR-based quantification and characterization of AAV vector and products, nucleic acid technologies and tools, including, but not limited to, short/long read next generation sequencing, genome integrity and composition, ddPCR-based quantification and characterization of AAV vector and products.
  • Experience in primary 2D/3D assay development, design/execution of nonGLP animal studies, AAV biology, capsid design, sh/miRNA biology, and/or analytical/process development is highly desired.
  • Ability to work collaboratively across a dynamic and collaborative scientific and development environment.
  • Excellent communication skills, both written and verbal, and strong interpersonal skills.
  • Experience working in neuromuscular, cardiovascular, liver, and/or lung disease areas.


The level of this position will be based on the final candidate's qualifications.

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we're proud of this, we know there is so much more we could do to help improve and extend people's lives. We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world's toughest medical challenges. Because the greatest risk in life, is the risk of never trying! Imagine what you could do here at Novartis!

Novartis Gene Therapies Benefit Summary:

Annual bonus, long term incentive, health insurance, paid vacation/holidays, potential flexible working arrangements (based on role) and an employee recognition program are available for this position, among many other benefits provided to employees of Novartis Gene Therapies.

Please note this job description is not designed to cover or contain a comprehensive listing of activities, duties or responsibilities that are required of the employee for this job. Duties, responsibilities and activities may change at any time with or without notice.

Novartis Gene Therapies is committed to creating a diverse environment and is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, national origin, genetics, disability, age, sexual orientation or veteran status.

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