Associate Manager - Human Tumor Immune Monitoring Group

We are seeking an experienced oncology researcher to join the human tumor immune monitoring group. The successful candidate will work on a team that develops and performs functional assays on primary human cells, including blood and tumor immune cells, tumor cells, and tumor associated fibroblasts. The candidate will manage the day-to-day laboratory operations and, will support clinical immune monitoring projects and develop exploratory assays on clinical biomarker samples collected from patients who are receiving Regeneron's cancer therapies. Some key goals of the team's work are to understand how our cancer therapies are working in the patients we treat, to identify features of anti-tumor immune responses, and to study mechanisms of immune evasion. The qualified individual should have a strong laboratory background in one or more areas of tumor biology, immunology, and/or immuno-oncology.

As an Associate Manager in Human Tumor Immune Monitoring Group, a typical day might include the following:

- Organize clinical samples and ensure accurate and timely sample registration and reconciliation

- Manage inventories of human samples purchased from vendors, including PBMC, serum, tumor tissues, etc.

- Manage inventories of plasmids, cell lines, viral stocks, peptides, etc.

- Perform tissue dissociation for cell enrichment and downstream assays

- Independently develop and execute primary human immune cell functional assays, including co-culture assays of immune cells and tumor cells

- Perform high-throughput T cell screening to determine antigen-TCR pairing

- Independently design multicolor flow cytometry panels (30 to 40 colors), operate high-parameter flow cytometers, and perform analysis

- In vitro cell engineering, characterization and functional assays

- Develop cell-based assays to study signaling pathways in immune modulation

- Execute cell-based molecular biology assays, including but not limited to protein analyses (immunoblotting, ELISA, immunoprecipitation, etc), quantitative assays of nuclear acids (RT-PCR, qPCR, RNAseq, etc)

- Oversee instrument maintenance and repair

This role might be a good fit for you if:

- You can work independently and collaboratively with other internal research and clinical teams to jointly develop and advance technology-forward methods to evaluate anti-tumor immune responses

- You are experienced in methods of human immune cell culture and functional assays

- You are skilled in the design of multicolor flow cytometry panels, operation of high-parameter instruments, and flow cytometry data analysis

To be considered for this position you must have minimally an MS (or higher) in Molecular Biology, Immunology or related discipline, and minimum of 5 years of experience in T cell biology and cancer biology. You should have minimum of 5 years of hands-on technical experience in tissue culture, with preference for primary cell culture experience, and hands-on technical experience in molecular and cell biology in the oncology field. Strong written and oral communication skills are required. Prior experience with high-throughput immunological screening and single cell sequencing including TCR sequencing is preferred. Experience in laboratory management is a plus. The candidate is expected to be able to independently design experiments and develop assays (in vitro and ex vivo) to study immune cell phenotype and function. In addition to hands-on participation in experiments, the candidate will develop standard protocols for clinical sites to preserve and process tissue and blood samples and ensure adherence to the protocols and trouble shoot as necessary. This position will require the individual to pass a physical before beginning employment.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.