Research Associate, Analytical Chemistry - Purification

San Francisco, CA, United States
Jul 07, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time

Nurix Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of small molecule therapies designed to modulate cellular protein levels as a novel treatment approach for cancer and immune disorders. Leveraging Nurix's extensive expertise in E3 ligases together with its proprietary DNA-encoded libraries, Nurix has built DELigase, an integrated discovery platform to identify and advance novel drug candidates targeting E3 ligases, a broad class of enzymes that can modulate proteins within the cell. Nurix's drug discovery approach is to either harness or inhibit the natural function of E3 ligases within the ubiquitin proteasome system to selectively decrease or increase cellular protein levels.

Nurix's wholly owned pipeline comprises targeted protein degraders of Bruton's tyrosine kinase, a B-cell signaling protein, and inhibitors of Casitas B-lineage lymphoma proto-oncogene-B, an E3 ligase that regulates T cell activation. Nurix is headquartered in San Francisco, California.


We are seeking a highly motivated individual with a 0-3 years of lab experience to join the small molecule purification group at Nurix.

This position will perform purifications of small molecule libraries by mass directed HPLC, run routine purity checks and submit samples for analysis by NMR. The candidate requires the ability to work in a fast-paced laboratory setting using state of the art analytical and preparative equipment. This role also requires basic lab / chemical handling safety and the ability to lift 40 lbs.

The candidate should have a strong desire to learn new techniques, stay up to date with purification trends, and an aptitude for robotic automation workflows. The ideal candidate will be self-driven, resourceful, organized, focused, and enjoy working in the dynamic team environment here at Nurix.

Required Qualifications
  • Minimum qualifications include a B.S. or equivalent degree in chemistry, analytical chemistry, or related field, with (0-3) years of industrial experience in purification of small molecules.
  • Experience with LCMS instrumentation as well as the interpretation of chromatograms.
  • Familiarity with basic wet lab and analytical chemistry techniques, including pipetting, sample dissolution, solution preparation, and rotary evaporation.
  • Aptitude with Microsoft Office Suite products, including Excel.

Bonus Qualifications
  • Familiarity with MassLynx, ChemStation, or Chromeleon software.

Fit with Nurix Culture and Values
  • Strong team orientation; highly collaborative
  • Solutions and results-oriented focus
  • Hands-on approach; resourceful and open to diverse points of view

Application Process

Nurix is an Equal Opportunity Employer offering a competitive salary and benefits package. Applicants should be legally entitled to work for any employer in the US.

Note to Employment Agencies: Please do not forward any agency resumes. Nurix will not be responsible for fees related to unsolicited resumes.