Principal Scientist - Pharmacokinetics and Drug Metabolism

South San Francisco, CA
Jul 07, 2021
Required Education
Masters Degree/MBA
Position Type
Full time


If you feel like youre part of something bigger, its because you are. At Amgen our shared missionto serve patientsdrives all that we do. It is key to our becoming one of the worlds leading biotechnology companies. We are global collaborators who achieve togetherresearching, manufacturing and delivering ever-better products that read over 10 million patients worldwide. Its time for a career you can be proud of. Join us.

Principal Scientist - Pharmacokinetics & Drug Metabolism


What you will do

Lets do this. Lets change the world. In this vital role you will add substantial scientific expertise to the discovery and non-clinical development of small molecule therapeutics. You will be responsible for establishing and implementing PKDM strategy to achieve project team goals integrating PKDM with other aspects of drug discovery including disease biology, chemistry/protein sciences, toxicology and clinical pharmacology to advance the best therapeutic candidates. In addition, you will make meaningful and innovative contributions to the fundamental understanding of the factors that affect the absorption, distribution, and clearance of small molecule therapeutics.

  • Serve as a functional representative and subject matter expert on the biotransformation and pharmacokinetics (PK) of small molecule therapeutics, communicate project team progress and issues, and collaborate with scientists cross-functionally

  • Evaluate and implement emerging in vitro and in silico tools to support the prediction of pharmacokinetics and drug interactions in humans

  • Work with disease and biology experts to design appropriate pharmacodynamic (PD) studies to evaluate biology, PD and/or efficacy models, and to establish PKPD relationships to best meet therapeutic objectives

  • Devise, articulate, and implement strategies for improvement of absorption, distribution, clearance and PK/PD properties for candidate molecules

  • Articulate risk and mitigation strategies for human PK predictions and clinical dose projections

  • Design and complete IND and NDA-enabling studies and reports to support regulatory submissions

Your specific contributions will depend on your expertise, interests, training, and experience. You will also have opportunities to learn and obtain experience with PKDM strategies for the discovery and non-clinical development of biological therapeutics.

In addition to the core responsibilities, the position provides the opportunity to pursue scientific inquiries into the fundamental physiological and biochemical factors that determine the absorption, distribution, and clearance of small molecule therapeutics. A collaborative and highly capable scientific community at Amgen is available to support these efforts. Interactions and collaboration with academic and other external scientists is encouraged.


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a Scientist with these qualifications.

  • Doctorate degree and 3 years of industry experience

  • Masters degree and 6 years of industry experience

  • Experience as a project team representative


What you can expect of us

As we work to develop treatments that take care of others, so we work to care for our teammates professional and personal growth and well-being.

  • Vast opportunities to learn and move up and across our global organization

  • Diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act

  • Generous Total Rewards Plan comprising health, finance and wealth, work/life balance, and career benefits

Apply now for a career that defies imagination

In our quest to serve patients above all else, Amgen is the first to imagine, and the last to doubt. Join us.

Equal Opportunity Statement

Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

We will ensure that individuals with disabilities are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request an accommodation.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.