Senior Scientist, Off-Target Characterization and Genomics

Cambridge, MA, United States
Jul 04, 2021
Required Education
Bachelors Degree
Position Type
Full time
Why Join Intellia?

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases.

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done.

We want all of our people to go beyond what is possible. We aren't constrained by typical end rails, and we aren't out to just treat people. We're all in this for something more. We're driven to cure and motivated for change. Just imagine the possibilities of what we can do together.

How you will Achieve More with Intellia

As a Senior Scientist, you will help support the characterization and quantitation of unintended off-target genome editing with CRISPR/Cas9 using high throughput next generation sequencing (NGS). You will work on various oncology and genetic disease areas across different stages of therapeutic development:
  • Apply your training in molecular biology and NGS associated with genomics, such as DNA purification, shearing, adapter ligation, PCR, NGS library purification and quantification
  • Evaluate, develop and conduct genome-wide off-target characterization experiments to support guide characterization for therapeutic development
  • Write and QC technical and study reports to support regulatory filings (IND or CTA equivalent), and then synthesize the results for effective communication across various levels of expertise
  • Participate in regulatory interaction meetings, responses to questions from regulators and strategic communication of off-target characterization results
  • Troubleshoot and optimize, both independently and in collaboration with colleagues
  • Accurately document project and sample information, protocols, and experimental details through the Laboratory Information Management System (LIMS) and Electronic Lab Notebook (ELN)
  • Use Amplicon -seq , RNA -s eq, Whole Exome -seq , Whole Genom e-seq , Genome wide -seq , Translocation -s eq and C h IP - Seq for O ff-target characterization.

About You

We are looking for a candidate with a PhD in Molecular Biology or related discipline, with relevant experience in academic or industrial setting. If you have strong communications skills (written and oral), coupled with exceptional time management skills and attention to detail, we encourage you to apply!

Meet your future team

The Genomics team are a fun, energetic, and passionate group of individuals, who are focused on pre-clinical NGS data support for IND or CTA packages. You will report directly to the Associate Director of the Screening and NGS Platform Development (SNPD). This hiring manager oversees Intellia's off-target characterization strategy and communication for therapeutic development of CRISPR/Cas9. The breadth of exposure to cutting edge gene therapy development will provide the candidate with exposure to the full spectrum of CRISPR therapeutic development in vivo and in cell-based therapies engineered with CRISPR.

The team is currently working mostly onsite to execute NGS workflows in a wet-lab environment. Therefore, we require a candidate to be currently local to Cambridge MA, or open to relocating. While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for growth of young scientists interested in a career in therapeutic biotechnology. If you join our team, you can expect to join a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patient's lives.


EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.