Senior Scientist, Cell Therapy Process Development

Location
Cambridge
Posted
Jul 04, 2021
Ref
5025436002
Required Education
Bachelors Degree
Position Type
Full time
JOB PURPOSE

We are seeking a talented and motivated individual to join the Upstream Process Development group as a Senior Scientist. This candidate will lead development of a production scale pluripotent stem cell-derived beta islet manufacturing process. The candidate will join an innovative multi-disciplinary team developing cell therapy manufacturing technologies to bring allogeneic PSC-derived beta cell therapies into clinical trials.

DUTIES AND RESPONSIBILITIES
  • Develop scale down models of pluripotent stem cell expansion and differentiation, customize media, and develop, optimize, and characterize at-scale upstream and downstream processes.
  • Drive scientific advances in our understanding of PSC bioprocessing
  • Collaborate closely with beta cell research program and hypoimmune PSC development program. Advise both programs on CMC considerations.
  • Create and manage technical development plans tied to tangible and time-bound deliverables
  • Adapt process for GMP-ready manufacturing. Tech transfer processes to other Sana sites and external manufacturing organizations.
  • Lead and manage scientific team. Maintain a functioning cell therapy bioprocess lab.

QUALIFICATIONS

Basic Qualifications
  • Ph.D. in scientific discipline w 5+ yrs experience in bioengineering, chemical engineering, or related field. BA or MS plus 8+ yrs or equivalent combination of education and work experience; Deep subject matter expertise and an emerging leader.
  • Strong knowledge of small scale process development, preferably in an allogeneic cell therapy industry context
  • Hands-on experience with stem cell culture and differentiation
  • Excellent communication, documentation, and presentation skills
  • The candidate should be a team player, highly organized and demonstrate curiosity and scientific rigor and excellent problem-solving skills.
  • Ability to engage in crucial conversations - providing and receiving feedback
  • Working safely in person on a predictable and regular in-person basis is an essential job function for this position and the Company requires that all individuals working in-person, subject to certain exceptions, be fully vaccinated against COVID-19.

Preferred Qualifications
  • Hands-on experience with PSC biology, bioengineering, differentiation and process development
  • Hands-on experience with bioreactor unit operations at bench and pilot scale
  • Working knowledge of DoE methods for experimentation and statistical analysis
  • Direct, hands-on industrial experience with biologics, gene, and/or cell therapy process development, including ownership of key process decisions
  • Strong understanding of culture media development
  • Understanding of the data package and reports required to advance processes into clinical manufacturing
  • Motivated, curious, comfortable working with highly technical projects and personnel
  • Direct industrial experience managing projects
  • Direct prior industrial experience managing 1-2 direct reports

WORKING CONDITIONS

This is a lab-based role, with occasional weekend work. Some travel required including tech transfer and CMO-related travel.

PHYSICAL REQUIREMENTS

Occasional lifting of bioreactors and media (up to approximately 20kg).

Lab work (standing)

To perform this job successfully, an individual must be able to perform each essential duty satisfactorily. The job description listed above is representative of the knowledge, skill, and/or ability required. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

At Sana, we believe that a diverse workforce strengthens us as a company and helps us to achieve our mission to meaningfully change the outcome of many human diseases. This belief is a pillar of our business and is critical to our success. Our goal is that Sana is the place for talented people to bring their authentic selves to work, to have a great career and to deeply, positively impact patients.

The Company is committed to providing a workplace free of discrimination and harassment based on race, color, religion, age, gender, national origin, ancestry, physical or mental or sensory disability (including the use of a trained guide dog or service animal by a person with a disability), genetic information, actual or perceived HIV or Hepatitis C infection, medical condition (cancer or a record or history of cancer and genetic characteristics), marital status, sexual orientation, sexual preference, pregnancy (including childbirth and related medical conditions), disability, veteran status, political ideology, taking or requesting statutorily protected leave, status as a victim of domestic violence, sexual assault or stalking, or any other basis prohibited by applicable law.

Core to our values, we believe there is nothing more important than the health and wellness of you and your family. We cover 100% of the cost for employee health coverage and offer generous time-off, parental leave, short and long term disability, financial wellness programs, a 401(k) Plan, Employee Stock Purchase Plan, commuter subsidy and a variety of wellness offerings to support each person individually.