Research Fellow, Neuroscience

Tarrytown, New York, United States of America
Jul 04, 2021
Required Education
Bachelors Degree
Position Type
Full time
The Neuroscience group is looking for a PhD scientist to join our dynamic and highly collaborative Neuroscience team. The new hire will support the development of new technologies for the identification and validation of new targets and support of ongoing targets in Neuroscience. The successful candidate should have expertise performing and analyzing electrophysiology experiments (eg. automated patch clamp platform: Port-a-Patch, QPatch or Patch-express and manual patch-clamp, brain slice patch clamp rig, in vivo field recording, EEG) and ideally experience with chemogenetics & optogenetics approaches.

As a Research Fellow on the Neuroscience team, a typical day might include the following:
• Setting up in vivo electrophysiology assays and conducting experiments to evaluate mechanisms or efficacy of various pathophysiologies or therapeutic targets using these assays
• Establishing chemogenetics, optogenetics, & imaging in mice and using these techniques to explore mechanisms of normal or pathological nervous system circuits
• Conducting in vivo experiments involving stereotaxic, local, or systemic injections to evaluate mechanisms of brain function or dysfunction or efficacy in models of disease
• Establishing ex vivo brain slice electrophysiology and conducting mechanistic experiments using these slices
• Evaluating and implementing new technologies as relevant
• Conducting research independently including innovating new ideas, designing and analyzing experiments, and trouble-shooting technical issues.

This role might be for you if:
• You have the ability to coordinate multiple projects independently.
• You have excellent communication skills as well as the ability to easily work with different groups both large and small.
• You have a keen eye for details.

To be considered for this opportunity, you must have a PhD with at least ten years of relevant research experience. Expertise in in vivo and in vitro electrophysiology. Innovative courage and the ability to craft experiments independently and trouble-shoot. Chemogenetics & optogenetics experience required. Experience with diverse in vivo procedures including stereotaxic surgery, and systemic and local injections also required. You should also possess a strong understanding of brain circuitry and anatomy. A strong record of innovation and research accomplishments in molecular immunology, immuno-oncology, or related field. Experience with antibody and/or cell therapies preferred. Experience independently crafting and carrying out in vivo studies in mice is required. Detailed knowledge of tumor and/or transplantation models strongly preferred. Ex vivo engineering and analysis of primary cells, especially HSCs. Multi-parameter flow cytometry (10+ color) and other immunology methods (EliSpot/EILSA, MSD, cytotoxicity, etc.) are required. Basic molecular biology and cloning skills required. Experience with high-throughput analytic methods-e.g. NGS and/or high-throughput screening method.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.