Staff Engineer, Purification Development Lead - Gene Therapy

Tarrytown, New York, United States of America
Jul 04, 2021
Required Education
Bachelors Degree
Position Type
Full time
The Preclinical Manufacturing and Process Development department is looking for a Staff Engineer, responsible for leading our Viral Production Core (VPC) purification process development group. The VPC performs process development and tech transfer of Regeneron's viral vector-based therapies, as well as supplying material for pre-clinical studies. This is a growth opportunity that combines the excitement and opportunity of a start-up with the security and institutional knowledge gained from working for a larger firm. In this role you will have the opportunity to cross train on upstream and analytical aspects to broaden your knowledge base.

As a Staff Engineer leading Viral Vector Purification Development, a Typical Day Might Include the Following:

  • Design, coordinate, and execute optimized, characterized and robust processes for the purification of viral vectors suitable for future GMP clinical production.
  • Lead, mentor and empower a team
  • Lead technology development, get results, and onboard new technologies.
  • Support laboratory upstream operations and analytical development and testing as needed.
  • Use expertise in theory and practice of manufacturing steps and analytical methods.
  • Maintain scientifically current (state of the art) laboratory environment and/or data systems.
  • Prepare and deliver effective oral presentations in area of expertise at internal and external professional meetings with minimal consultation with supervisor. Share multi-functional skills and knowledge at a wide variety of meetings. Write complete internal and/or external ""publications"" that require minimal revisions (i.e., Process transmittals, development reports, patents, Peer Reviewed publications etc.).
  • Participate in operational collaborations with Regeneron groups or academic/industry collaborators.
  • Drive continuous improvement, and perform long term planning for laboratory related personnel, supplies and equipment.

This Job Might Be For You If::

  • You have experience applying engineering principles and experimental design toward the development of manufacturing processes of biotherapeutics.
  • You have a thorough understanding of statistical analysis principles used in Design of Experiments to efficiently plan process development, optimization and characterization studies to provide statistically meaningful outputs and direction for future studies and final processes.
  • You have experience in successful technology transfer of biotherapeutics to GMP Manufacturing facilities.
  • You are aware of current Regulatory Requirements for biotechnological products, including viral clearance requirements
  • You have a history of developing purification steps in bioprocesses.
  • Prior experience with producing AAV-based gene therapies or knowledge of viral biology is a plus.

You can operate some of the following equipment:

Akta Explorer/Avant, Akta Ready, pilot and bench scale microfluidizers, Depth filtration, Tangential flow filters, Normal flow filters, Chromatographic columns, HPLC, UPLC, Chemical Fume hood, Empower, Unicorn, LIMS.

This role requires a PhD with 2 - 7+ years experience, or BSc/MSc with demonstrated ability.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.