Scientist, Cellular Therapy
Obsidian Therapeutics is pioneering engineered cell and gene therapies to deliver transformative outcomes for patients. Obsidian’s programs apply our CytoDriveTM technology in Cell and Gene therapy products to control expression of proteins for enhanced therapeutic efficacy and safety.
We’re proud of our diverse talented team and committed to cultivating an environment of inclusion where each person feels a strong sense of belonging and is supported to continuously learn and contribute their best work. Our research team is based in the heart of Cambridge, MA, and our Technical Development and Manufacturing will soon be moving to a brand new facility in Bedford, MA to support our growth. Obsidianites enjoy a highly collaborative culture, competitive salary and benefits, and potential for ownership through stock options.
We are looking for a talented, creative, collaborative, flexible scientist with strong immunology experience to join the Cell Therapy team as a key contributor to preclinical research developing new pipeline candidates. You’ll be a vital part of a collaborative team working to achieve Obsidian’s vision by translating innovative science into meaningful medical breakthroughs for patients.
This is a unique opportunity in a well-funded pre-clinical company with blue chip investors, field-leading advisors, and a highly experienced team. You’ll help us build a dynamic, innovative, passionate, collaborative, and successful organization focused on delivering transformative therapies in areas of greatest clinical need.
- Lead preclinical proof of concept research activities toward the development of engineered cell therapy products
- Design workplans to quickly triage concepts for new pipeline candidates
- Mentor research associates in the design, execution, and analysis of experiments
- Isolate, engineer, expand and characterize human tumor infiltrating lymphocytes (TILs)
- Develop and apply cell-based immune assays to assess TIL function in a variety of in vitro co-culture systems
- Work closely with the In Vivo Pharmacology team to design, coordinate and analyze in vivo adoptive cell transfer studies
- Work closely with the Discovery team to conceptualize and optimize constructs for TIL engineering
- Independently design experiments, meticulously execute bench work, analyze data, and troubleshoot assays
- Communicate results at internal and external meetings
- PhD in Immunology or a related field with 3+ years postdoctoral training, industry experience preferred
- Creativity in conceptualizing new pipeline concepts and innovation in designing proof-of-concept experiments
- Expertise in cell culture and functional assay development using primary human immune cells
- Expertise in various ex vivo immunology methods such as T and NK cell genetic engineering, isolating human and mouse immune cells, multiparameter flow cytometry, cytotoxicity assays, cytokine quantitation and intracellular cytokine staining
- Strong oral communication skills
- A highly motivated and collaborative work style, with ability to work independently and as part of a team in a matrixed environment
- Ability to quickly learn and adapt to a fast paced, rapidly developing environment
- Scientific rigor in the design, execution, analysis, and troubleshooting of scientific experiments
- Demonstrated success in driving research projects, mentoring and training junior staff
- Excellent organization, record keeping, multi-tasking, and communication skills
- Experience with tumor infiltrating lymphocytes (TIL)
- Experience with small scale viral vector production, titration, and vector copy number analysis
- Experience with viral vector transduction of primary human immune cells
- Cellular immunotherapy experience
- Experience with genetic engineering
Obsidian is proud to be an equal opportunity employer, cultivating a welcoming and diverse environment. All applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, disability, age, veteran status or any other applicable legally protected characteristics.