Associate Director/Director, High Throughput Screening & Assay Development

Seattle, WA, United States
Jul 02, 2021
Required Education
Bachelors Degree
Position Type
Full time
Associate Director/Director, High Throughput Screening & Assay Development

This position will lead a High Throughput Screening (HTS)/Robotics team at Omeros Corporation with the goal of discovering new small molecule drug candidates and assisting with small molecule optimization.

Good things are happening at Omeros!

Come join our Omeros Discovery Team!

Who is Omeros?

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market and orphan indications targeting inflammation, complement-mediated diseases, disorders of the central nervous system and immune-related diseases, including cancers. In addition to its commercial product OMIDRIA (phenylephrine and ketorolac intraocular solution) 1%/0.3%, Omeros has multiple phase 3 and phase 2 clinical-stage development programs focused on complement-mediated disorders and substance abuse. Omeros also has a diverse group of preclinical programs including GPR174, a novel target in immuno-oncology that modulates a new cancer immunity axis recently discovered by Omeros. Small-molecule inhibitors of GPR174 are part of Omeros' proprietary G proteincoupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and their corresponding compounds. The company also exclusively possesses a novel antibody-generating platform.

What are your job responsibilities?

  • Assay development and for managing routine Structure-Activity Relationship assays
  • Data processing and management
  • Compound inventory and distribution
  • HTS and robotics & chemical library management
  • Maintaining an orderly and safe work environment
  • Using good judgement, take appropriate precautions and follow prescribed safety measures ensuring safety in the lab
Education, Experience, Skills, and Knowledge Required:

  • PhD with 10+ years of experience in the biopharmaceutical industry.
  • Experience running a HTS lab
  • A successful history of managing laboratory personnel
  • Experience configuring and programming robotic systems
  • Fundamental understanding of biology/engineering/physics as it relates to robotics equipment, biochemical reactions, assay readout instrumentation, liquid handling and HTS
  • Assay development experience
    • Defining assay parameters & optimizing protocols
    • Experience with biochemical and cell-based assays
    • Experience with the fundamentals of enzyme kinetics and protein binding kinetics are required
    • Ability to build/design custom auxiliary devices for robotic systems and/or write custom code are considered an asset
  • Data management experience
    • Experience working with databases (i.e. Excel, Access, SQL Server, Oracle), hands-on experience with Abase is a plus
    • Programming with Visual Basic for Applications in Excel
  • Experience procuring compound libraries
  • Ability to manage compound inventories (screening libraries and/or in-house chemical collections)
  • Good communication and interpersonal skills
  • Detail oriented
Behavioral Competencies Required:

  • Willingness to work with other team members, share and encourage new ideas, strive to find the best solutions and build team competencies over time
  • Having a good understanding of the goals and longer-term direction
  • An eye toward self-improvement, productivity and gaining knowledge
Supervisory Responsibilities:

  • Carries out supervisory responsibilities in accordance with the organization's policies and applicable laws
  • Responsibilities may include interviewing, hiring, and training employees; planning, assigning, and directing work; appraising performance; rewarding and disciplining employees; addressing complaints and resolving problems
Physical Demands Required:

  • Intermittent physical activity including bending, reaching, pushing, pulling, or lifting up to 40 lbs.
  • Occasionally, the job may require moderate lifting of equipment and/or liquid carboys, working with acids/bases or small quantities of potentially hazardous materials
  • May encounter prolonged periods of sitting or standing
  • This position requires working around hazardous materials
Omeros is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to status as a protected veteran or a qualified individual with a disability, or other protected status such as race, religion, color, national origin, sex, age, marital status, or any other factor determined to be unlawful by federal, state, or local statutes.

It is our policy to provide reasonable accommodation to anyone with a disability who needs assistance completing the job application process. If you need assistance, you can either send an e-mail to or contact Omeros, asking for Human Resources, at (206) 676-5000