Senior Principal Scientist , Early Development Informatics & Predictive Sciences

Redwood City, California
Jul 01, 2021
Required Education
Bachelors Degree
Position Type
Full time

At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

Senior Principal Scientist / Associate Director / Director, Early Development Informatics & Predictive Sciences 


We are seeking an innovative scientist to join our Early Development Informatics and Predictive Sciences team. This group of computational biologists is responsible for advancing Bristol-Myers Squibb’s industry-leading Early Clinical Development pipeline through the strategic application of cutting-edge bioinformatics approaches. The scientists in this group design experiments and analyze both pre-clinical and clinical-omics data sets, including RNA-Seq, exome, single-cell sequencing, cytokine and proteomics to develop patient enrichment strategies, novel biomarkers, diagnostics and guide drug development decisions. The group interacts with and influences all aspects of R&D at BMS, from early discovery through late-stage development. This scientist can work in any of the following locations, Seattle WA, Redwood City CA, San Diego CA, Cambridge MA or Lawrenceville NJ.  


Informatics and Predictive Sciences (IPS) has a mission to drive predictive informatics research across BMS. The role of IPS encompasses a broad range of computational research, from cutting-edge bioinformatics to discover new therapeutic targets, to applied machine learning to optimize clinical trials and predict patient outcomes. The Early Development Predictive Science team focuses on cutting edge informatics research to progress BMS' Early Development clinical pipeline. 



This individual would be responsible for leading the disease area Early Clinical Development Predictive Sciences strategy in collaboration with Early Clinical Development and Translational research and manage or mentor scientists in the group to deliver on this strategy. They would also be responsible for performing analysis of omic datasets including RNASeq, WES, single cell sequencing and/or cytokines to inform trial design, enable patient enrichment strategies and early stage clinical development of the BMS pipeline. They would develop and drive collaborations with other bioinformaticians, statisticians, biologists and clinicians to implement and execute bioinformatics analysis to impact our Early Phase Clinical Development portfolio.  



  • Ph.D. in bioinformatics, molecular biology, statistics, physics, genetics, or similar and 7+ years relevant experience or Masters and 10+ years experience or BS and 12+ years of relevant experience

  • Background in Oncology or Immunology and experience working with clinical trial data in a drug development setting 

  • Broad experience with data generated by one or more high-throughput molecular assays: next-generation sequencing, metabolomics, flow cytometry, mass spectrometry proteomics, etc. 

  • Strong experience in the use of a high-level programming language such as R, Python or MATLAB for complex data analysis and reproducible research practices 

  • Strong problem-solving and collaboration skills, rigorous and creative thinking 

  • Exceptionally strong communication, data presentation and visualization skills 

  • Ability to strategically prioritize analysis across a large number of projects 

  • Proven ability to work across large organizations to define and solve problems that will benefit the whole.

  • Capable of establishing strong working relationships across an organization

  • Strong publication record 


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. 

Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application, or any part of the recruitment process direct your inquiries to Visit to access our complete Equal Employment Opportunity statement.