Scientist II / Senior Scientist, Preclinical Science

About Ambrx:

Ambrx, Inc. is a biopharmaceutical company with a mission to deliver breakthrough protein therapeutics. Ambrx is based on a fundamental advance in protein biosynthesis that enables the company to genetically engineer proteins with new amino acid building blocks beyond the common twenty, enabling the biosynthesis of proteins with new physical, chemical and pharmacological properties. At Ambrx, we are dedicated to assembling and developing an exceptional team and a breakthrough technology to create the next generation of protein-based medicines.

KEY RESPONSIBILITIES

• Independently contribute to drug discovery project planning, advancement, and leadership
• Design and perform in vitrobinding and cellular assays to assess drug candidate effects on innate and adaptive immune functions
• Analyze and interpret experimental results and present findings at project team meetings
• Provide subject matter expertise to diverse project teams related to basic immunology, immuno-oncology, target biology, and disease pathogenesis
• Use competitive intelligence, analytical thinking, and domain expertise to develop new project proposals
• Support and manage external collaborations, including CROs and collaborators
• Desirable: may contribute to design and execution of in vivopharmacology models
• Manage daily activities and professional development of one or more Research Associates
• Maintain detailed records in laboratory notebooks in accordance with company policy
• Write and review technical reports, SOPs, and scientific manuscripts for publication

PROFESSIONAL EXPERIENCE/QUALIFICATIONS

• PhD degree in Immunology (or Mol/Cell Biology/Biochem with immunology expertise)
• For Sr. Scientist: 5+ years of industry drug discovery experience
• Deep understanding of human immunology and immuno-oncology field
• Experience designing and performing in vitro assays using cell lines and primary human immune cells, including multi-step stimulation and immune-tumor cell co-culture systems
• Skilled in standard immunological, and cell biology techniques including flow cytometry, ELISA/MSD/HTRF/etc, and primary immune cell isolation and culture
• Experience with in vivo pharmacology systems is preferred
• Demonstrated ability to organize and communicate complex data sets concisely
• Excellent organizational, time-management, and multi-tasking skills
• Consistently uses analytical thinking, persistence, and creativity to overcome challenges
• Demonstrated ability to progress projects within a complex, matrixed, organization
• Excellent verbal and written communication and interpersonal skills

How to Apply

To be considered as an applicant, please submit your resume/CV referencing the specific position of interest and position code.. Applicants whose qualifications and experience most closely match the position requirements will be contacted for further evaluation. Ambrx offers competitive compensation & benefits.  EOE