Associate Scientist - Bioassay Development

Regeneron's Bioassay group in the Therapeutic Proteins Department is looking for a highly motivated Ph. D. level Scientist with a strong background in molecular and cellular biology to join a fast-paced and dynamic group for assay development and high-throughput screening in early drug development. In the role of Scientist, you will develop bioassays to interrogate the in vitro function and regulation of a target protein and work collaboratively with other scientists of bioassay teams and cross-functional teams to push forward multiple projects. Experience in high-throughput screening is desirable, and experience in primary cell-based assays is a plus.

A Typical Day in the Role of Associate Scientist Might Look Like:

• Develop in vitro cell-based assays, perform high-throughput screens and characterize lead candidate antibodies in support of the Regeneron's Velocimmune antibody pipeline :100%
• Design appropriate bioassays independently according to the mechanism of action of a target protein for high-throughput screening and lead antibody characterization
• Contribute effectively to assay development efforts by crafting, performing and optimizing cell-based assays (e.g. luciferase, Ca2+ flux, HTRF etc.), primary assays (eg. ADCC and ADCP etc.), enzymatic and ELISA-based assays, and high content imaging-based assays in 96- or 384-well format
• Characterize the expression and regulation of a target protein by flow cytometry, immunocytochemistry, and immunoblotting
• Design and generate stable cell lines with various techniques (eg. Lipofectamine transfection, virus transduction, and CRISPR/Cas9 etc) for bioassays, and isolate cells from PBMCs for primary assays
• Perform mammalian cell culture with adherent and suspension cells
• Analyze data and prepare impactful summary slides efficiently for presentations
• Manage and push forward multiple projects efficiently to meet timelines
• Interact effectively within bioassay teams and cross-functional teams
• Keep up with advances in assay technology and relevant disease biology
• Communicate results effectively to supervisor and senior managements
• Record experiments accurately in electronic notebook in a timely manner

This Role Might Be For You if You:

• Can work on multiple projects simultaneously
• Have excellent record-keeping and time management skills
• Possess the ability to absorb new information rapidly
• Are highly self-motivated and able to advise the course of their own work without extensive supervision

This role requires a PhD degree in cell biology, molecular pharmacology or a related field with 0-2 years of postdoctoral experience. In-depth knowledge of signal transduction pathways, mammalian cell culture, cell line generation, techniques of biochemistry, and cellular and molecular biology is required.
Expertise in multi-well assays, cell-based assays, ELISA, flow cytometry, drug screening experience is highly preferred. Exposure to primary cell-based assay development is preferred.

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.