Research Associate II, In-Vivo Neuroscience

Description

BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect a relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Research & Development group is responsible for everything from research and discovery to post-market clinical development. Research & Development involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first-in-class and best-in-class therapeutics that provide meaningful advances to patients who live with rare diseases. Come join our team and make a meaningful impact on patients’ lives.

Summary

We are searching for a highly motivated and experienced neuroscience Research Associate II (RA II) to join the Model Development group in Biology Research department. The candidate will be responsible for organizing and performing in vivo experiments, implementing new methodology, conduct data acquisition and analysis, and present experimental findings to internal teams. This position offers a unique career opportunity to work in a dynamic matrix-based team environment on multidisciplinary aspects of drug development. The successful candidate will interact with other members of the Biology Research department as well as collaborators to support our therapeutic discovery programs in neuroscience. Candidates should be scientifically flexible in working in a variety of disease areas as part of diverse team.

Applicants should have a MS or BS in a relevant field with solid hands on in vivo experience. The ideal candidate will work collaboratively on project teams, being resourceful, organized, independent, and detail oriented.

Responsibilities

• Organize and maintain animal colonies (rodents)
• Animal husbandry, such as breeding, genotyping and weaning
• Perform a variety of in vivo lab work, including but not limiting to: drug dosing (ip, iv, sc, icv, po), PK/PD studies, behavior measurement and necropsy
• Perform data recording and statistical analysis
• Be able to write and track IACUC and other animal protocols
• Present results, conclusions, and implications to the group
• Document all experimental procedures and data in ELN
• Share responsibility for lab maintenance duties
• Other duties as assigned

Requirement

• Bachelor’s degree and at least 4 years of experience; Master’s degree with at least 2 years of relevant experience
• Ability to recognize and adhere to IACUC standards of in vivo research is essential
• Routine In vivo handling (mouse/rat)
• More than 2 years of experience in animal dosing: ip, iv, sc, icv, im, it etc.
• Precise documentation of SOPs and results
• Excellent communication skills including presentation of data at project team and department level.
• Interest to learn new technology
• Ability to work with Microsoft office suite
• Able to commute to different locations based on task requirement (mileage will be compensated)
• Schedule should be flexible based on animal care needs

Preferred

• Neuroscience background is highly desirable
• Experience with electrophysiology is highly desirable including any of the following: extracellular recording, patch clamp recording, field potential recording, or EEG recording
• Experience with rodent model of neurological disorders
• Experience with cell/tissue culture
• Strong statistics background or programming skills (computer savviness is a plus)