Scientist, ADC Bioassay Development
- Employer
- Regeneron Pharmaceuticals, Inc.
- Location
- Tarrytown, New York, United States of America
- Start date
- Jun 19, 2021
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- Discipline
- Science/R&D, Bio-Assay Development, Biotechnology
- Required Education
- Bachelors Degree
- Position Type
- Full time
- Hotbed
- Pharm Country, Best Places to Work
Job Details
A Typical Day in the role of Scientist would look like:
- Develop, optimize, troubleshoot, and execute cell-based assays in 96 and 384 well formats for small molecules, biologics, and/or antibody drug conjugates (assays include: viability/cytotoxicity, luciferase reporter, membrane potential, multi-color flow cytometry, high content imaging, FRET, alphaLISA, etc.)
- Screen small molecules, biologics, and antibody drug conjugates for functional activity using cell-based 96 and 384 well formats
- Determine target and antibody intracellular localization and turnover (assays/methods include: internalization, co-localization to intracellular organelles, recycling, degradation, etc.)
- Lead cell-based assay development and screening projects from discovery to IND
- Mentor/manage junior lab associates
- Culture mammalian tumor and immune cell lines and primary cells
- Engineer cell lines (overexpression and knockout via CRISPR)
- Operate flow cytometers (iQue, Cytoflex), high content imaging instruments (Opera Phenix), and plate readers (Victor, Envision)
- Actively participate in and present work at collaborative group meetings
This Role Might Be For You If:
- Can work on multiple projects simultaneously
- Have excellent record-keeping and time management skills
- Possess the ability to absorb new information rapidly
- Are highly self-motivated and able to advise the course of their own work without extensive supervision
This role requires a PhD in Biology or a related field with 0-3+ yrs proven experience. Experience in mammalian cell culture, cell engineering, cell-based assay development and screening experience preferred. Familiarity with antibody drug conjugates, and protein trafficking preferred. Flow cytometry and confocal microscopy expertise a plus.
Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!
Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.
Company
Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to seven FDA-approved treatments and numerous product candidates in development, all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye disease, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, infectious diseases, pain and rare diseases.
Regeneron is accelerating and improving the traditional drug development process through our proprietary VelociSuite® technologies, such as VelocImmune® which produces optimized fully-human antibodies, and ambitious research initiatives such as the Regeneron Genetics Center, which is conducting one of the largest genetics sequencing efforts in the world.
Stock Symbol: REGN
Stock Exchange: NASDAQ
- Website
- https://www.regeneron.com/
- Phone
- 914-847-7000
- Location
-
Corporate Headquarters
777 Old Saw Mill River Road
Tarrytown
New York
10591
United States
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