Postdoctoral Researchers (Novel CRISPR-Cas Systems)

Brisbane, CA, United States
Jun 17, 2021
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time


Mammoth Biosciences is harnessing the diversity of nature to power the next-generation of CRISPR products. Through the discovery and development of novel CRISPR systems, the company is enabling the full potential of its platform to read and write the code of life. By leveraging its internal research and development and exclusive licensing to patents related to Cas12, Cas13, Cas14 and CasPhi, Mammoth Biosciences is advancing disease detection and treatment using its novel CRISPR systems that can deliver on the promise of precision medicine across diagnostics and therapeutics. Furthermore, Mammoth's CRISPR technology platform will enable new solutions in life science research, healthcare, agriculture, biodefense and more.

Based in the San Francisco Bay Area, Mammoth Biosciences is co-founded by CRISPR pioneer and Nobel Prize winner Jennifer Doudna and principal founders Trevor Martin, Janice Chen, and Lucas Harrington. The firm is backed by top institutional investors including Decheng, Mayfield, NFX, and 8VC, and leading individual investors including Brook Byers, Tim Cook, Bob Nelsen, and Jeff Huber.


Our small-size proteins, such as Cas14 and CasPhi, are poised to transform disease treatment enabling novel editing approaches and delivery options that are difficult to achieve or not even possible with previously described CRISPR-Cas systems. Our teams are responsible for discovering and engineering novel CRISPR systems, establishing CRISPR-based diagnostics, and translating our unique CRISPR technology into therapeutic treatments with the ultimate goal of cures for indications with high medical need.


Mammoth is seeking two Postdoctoral Researchers to characterize novel CRISPR-Cas systems over a period of two years. The successful candidates will join Mammoth's Discovery team, which is responsible for identifying, screening and developing novel Cas nucleases for genome editing and in vitro diagnostic applications. Postdoctoral Researchers will drive their own research projects under the supervision of the Discovery team's senior research staff.

At the beginning of the research term, the postdoctoral researchers will receive a list of CRISPR-Cas system candidates from the Discovery team staff. The postdoctoral researchers will then plan and execute research projects to (i) determine the function and/or enzymatic activity of candidate Cas proteins & RNAs and (ii) demonstrate utility of these Cas components for diagnostic and/or genome editing applications. The postdoctoral researchers are encouraged to incorporate a diversity of approaches into their research projects and will receive training or support in the areas of the Discovery team's existing strengths (eg. bioinformatics, high-throughput screening, Cas enzymology and laboratory automation).


    • Plan and execute a two-year research program to characterize novel CRISPR-Cas systems
    • Disclose inventions for patent filings
    • Publish and present research findings both internally and externally





    • PhD in Biochemistry, Molecular Biology, Microbiology or a related field
    • Strong track record of basic scientific discovery demonstrated by first-author publication(s) in high impact journals





    • Hands-on experience in one or more of the following disciplines: protein-nucleic acid interactions, heterologous expression in bacterial & archaeal hosts, next-generation sequencing assays, phylogenetic analysis of protein & RNA, molecular cloning.
    • Excellent spoken and written communication skills
    • Self-motivated attitude





    • Company-paid health/vision/dental benefits
    • Unlimited vacation and generous sick time
    • Company-sponsored meals and snacks
    • Wellness, caregiver and ergonomics benefits
    • 401(k) with company matching


It is our policy and intent to provide equal opportunity to all persons without regard to race, color, religion, political affiliation, sex/gender (including gender expression/identity, pregnancy, childbirth and related medical conditions), marital status, registered domestic partner status, sexual orientation, age, ancestry, national origin, veteran status, disability, medical condition, genetic characteristics, and/or any other basis protected by law. This policy covers all facets of employment including, but not limited to: recruitment, selection, placement, promotions, transfers, demotions, terminations, training, and compensation.