Scientist, Engineering Lead for Novel Bispecifics

We are seeking a Ph.D. scientist to join the Antibody Engineering group in Bispecific Antibodies Department at Regeneron. This individual will lead the effort to develop novel bispecific molecules across multiple therapeutic areas such as oncology, auto-immune disease, infectious disease, muscle/metabolism and neurosciences in our state-of-the-art research facility. You will also be responsible for developing novel technology platforms to enable the screening and creation of next generation antibody therapeutics. This highly visible role will require the candidate to collaborate and work with committed scientists in a science-driven and multidisciplinary team.

As Scientist, Engineering Lead for Novel Bispecifics, a typical day may include the following:

- Target proposal and design of novel bispecific and multi-specific antibodies based on in-depth understanding of biology
- Utilize structural modeling and analysis for rational engineering of novel therapies
- Construct, purify and characterize novel bispecifics and multi-functional therapeutic modalities
- Perform engineered and primary cell based assays to analyze activation, inhibition and mechanism of action of novel bispecifics and alternative format molecules
- Develop platform technology in engineering screening, molecular modality and molecular delivery
- Independently analyze data and provide accurate summary to leadership and present data at cross-functional meetings with scientific rigor
- Develop in-depth scientific knowledge in area of research focus, propose new ideas and contribute to project direction intellectually
- Collaborate and develop close scientific partnership with other functional areas

This role may be for you if:

- You are keen upon applying antibody engineering and structural biology expertise to drug development
- You have demonstrated track of record for innovative solution to challenges
- You have excellent organizational, multi-tasking and communication skills
- You can work collaboratively in a fast-paced team environment
- You have proven ability to independently design and execute experimental plan
- You are result-driven, with critical thinking, and have proactive aptitude for learning

To be considered for this role, you must have a Ph.D. in Immunology, Cell Biology or Molecular Biology with 3-5 years post-doctoral or industry experience. Demonstrated experience in antibody/protein engineering and structural biology with a proven track of publication record. We are seeking strong hands-on skills with DNA cloning, protein expression, purification and biochemical characterization. Possess experience with mammalian cell culture, cell-based assay development and FACS analysis. We are looking for an in-depth knowledge in one of the following areas: immunology, immuno-oncology, muscle metabolism or neuroscience. Familiar with structure modeling and analysis. The following skills are preferred, but we would be willing to train on the job. These include flow cytometry based cell assays and methods for non-protein-based delivery (such as DNA, AAV and/or mRNA).

Does this sound like you? Apply now to take your first steps toward living the Regeneron Way! We have an inclusive and diverse culture that provides amazing benefits including health and wellness programs, fitness centers and stock for employees at all levels!

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, nationality, national or ethnic origin, civil status, age, citizenship status, membership of the Traveler community, sexual orientation, disability, genetic information, familial status, marital or registered civil partnership status, pregnancy or maternity status, gender identity, gender reassignment, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you think you may need.