Scientist, Immunology

Company Description:

Molecular Templates is a clinical-stage biopharmaceutical company focused on the discovery and development of differentiated, targeted, biologic therapeutics. Our proprietary biologic drug platform technology, known as engineered toxin bodies, or ETBs, leverages the resident biology of a genetically engineered form of Shiga-like Toxin A subunit to create novel therapies with potent and differentiated mechanisms of action for cancer and other serious diseases. MTEM currently has multiple clinical-stage ETB candidates in development including MT-5111, TAK-169, and MT-6402. Additional preclinical compounds derived from our ETB platform technology are being advanced toward clinical development. Additional information about Molecular Templates can be obtained at www.mtem.com.

Position Overview:

Molecular Templates is seeking an accomplished and highly motivated Scientist to join the Immunology group as part of the research and development (R&D) team. This position will be primarily lab-based and focused on the generation, characterization and evaluation of immune cell subsets and their interactions with immunotoxins. The Scientist will contribute to the strategic design of in vitro, ex vivo, or in vivo studies which will require expertise in utilizing flow cytometric and immunoassay techniques to evaluate immune-based approaches to leverage immunotoxin biology. The Scientist is expected to work on projects with minimal direct supervision and will be expected to apply good judgment within defined procedures and practices to define appropriate actions. The Scientist may work with more junior team members to train and mentor them. In addition, they may lead R&D projects to drive the forward progress of pipeline candidates at the discretion of the management team and in line with R&D priorities.

Job Responsibilities will include:

• Independently designs, executes, and troubleshoots experiments in order to evaluate activity of novel biologics and ETBs
• Analyzes data and draws logical conclusions to define further action and effectively communicate to team members and management in a timely manner
• Maintain knowledge of scientific trends, industry processes and pipeline target literature through readings, conferences and seminars in order to contribute to strategic development of novel ETB platforms
• Document all procedures in an accurate and timely manner
• Conduct general laboratory duties, including ordering supplies and maintaining inventory and laboratory equipment as needed
• Will function as a subject matter expert and point of contact for the specific functions/equipment within the department
• With guidance from manager executes and manages new projects, as needed.
• Exercises good judgment within defined procedures and practices to obtain desired results
• Independently mentors junior team members and may be responsible for direct reports at the discretion of the management team
• May interface with various departments and serve as internal consultant, as needed
• Will interface with external CRO or Vendors to deliver on project goals
• Based on methods utilized across industry, develop immunology-based assays for use at MTEM to describe unique ETB-induced biology. This would include assay development and validation, SOP generation and training
• Displays technical expertise in flow cytometry, cell sorting, immuno-assay, primary cell culture, and cell based or molecular immunological techniques
• Will perform and interpret cell-based assays including those assessing viability and cell-death characterization
• With guidance from manager, able to communicate high level immunological concepts across departments and to leadership teams via a range of presentation mediums
• Other duties and responsibilities may be assigned by supervisor, as needed

Qualifications:

• Master's degree with 4+ years of relevant laboratory experience; or PhD in Immunology or related field with 2+ years of relevant laboratory experience
• Excellent written and verbal communication skills
• Excellent computer skills with knowledge of spreadsheet, word processing, graphing, statistical analysis software, and cloud-based data storage
• Excellent problem-solving and analytical skills applied to investigations
• Excellent project management, time management, and multi-tasking skills
• Proven ability to design research projects independently and provide thought-leadership
• Ability to manage competing priorities or projects and meet deadlines
• Ability to function independently and exercise good judgement, as well as work closely in cross-functional teams to support multiple pre-clinical stage programs
• Ability to clearly and efficiently document, communicate and present complex data sets
• Ability to function in a fast-paced, high-growth and team-based work environment
• Experience in primary cell culture and co-culture assays, required
• Record of mentoring or training junior team members to success highly preferred
• Demonstrated knowledge of T cell development, subsets, and function, preferred
• Experience in over-expression cell-line generation, preferred
• Experience in multiparameter flow cytometric design, execution, and analysis preferred

Reporting Structure:

This position currently may have supervisory responsibilities. This position reports to Immunology management, R&D.

Molecular Templates, Inc. is an Equal Opportunity Employer and offers competitive salaries and benefits.

Molecular Templates Inc https://mtem.isolvedhire.com