Sr. Research Associate 1/2

Location
Novato, California
Posted
Jun 15, 2021
Ref
o61pffwv
Required Education
Bachelors Degree
Position Type
Contract
BioMarin is the world leader in delivering therapeutics that provide meaningful advances to patients who live with serious and life-threatening rare genetic diseases. We target diseases that lack effective therapies and affect relatively small numbers of patients, many of whom are children. These conditions are often inherited, difficult to diagnose, progressively debilitating and have few, if any, treatment options. BioMarin will continue to focus on advancing therapies that are the first or best of their kind.

BioMarin’s Technical Operations group is responsible for creating our drugs for use in clinical trials and for scaling production of those drugs for the commercial market. These engineers, technicians, scientists and support staff build and maintain BioMarin’s cutting-edge manufacturing processes and sites, provide quality assurance and quality control to ensure we meet regulatory standards, and procure the needed goods and services to support manufacturing and coordinating the worldwide movement of our drugs to patients. Come join our team and make a meaningful impact on patients’ lives.

SUMMARY

The selected candidate will work in the Chemical, Formulation and Device Development (CFDD) group to advance therapeutic proteins, peptides, and gene therapy vectors for clinical and commercial applications. The candidate will be responsible for parenteral and solid dosage formulation development, product characterization and supporting manufacturing processes for drug products.  The selected candidate should possess strong analytical skills, be a self-starter and willing to work collaboratively in a dynamic team environment.

 RESPONSIBILITIES
  • Independently establish new techniques, methods, and procedures based on evolving project demands
  • Understand company goals and anticipate technologies and resources needs to meet those goals
  • Possess advance project management and problem solving skills to deliver reliable and timely results
  • Consistently deliver effective oral presentations to departmental and cross functional groups
  • Work collaboratively with CFDD group and external collaborates to foster teamwork
  • Use experience and understanding of literature to independently design, execute, and interpret complex sets of experiments in order to develop parenteral and solid dosage formulations
  • Demonstrate technical expertise and have sufficient experience in a broad range of basic and specialized methods
  • Employ various analytical instruments to characterize protein molecules
  • Provide concise and quantitative analysis of data and interpretation of experimental results
  • Conduct physicochemical and biophysical characterization of lead molecules
  • Integrate technical knowledge, advance project management and problem solving skills to deliver reliable and timely results
  • Support technology transfer activities to contract laboratories and or CMOs
  • Write experimental protocols and technical reports summarizing development work
  • Contribute to scientific publications and regulatory submissions as appropriate
  • Maintain good and timely documentation of experiments
  • Report project progress to manager in timely manner
  • Train and develop junior staff as needed

 

EDUCATION

 

  • Bachelors or Masters degree in the Pharmaceutical Sciences, Biochemistry, Biophysical Chemistry or related discipline
 REQUIRED SKILLS

 

  • Excellent communication, collaboration and writing skills
  • Demonstrated ability to present results in both oral and written formats is required
  • Proficient with broad use computer applications such as MS Office and specialized statistical software applications as needed for job.
  • Must be willing to work on multiple projects
  • A strong team player with good collaborative and people skills
  • Strong organization and prioritization skill, attention to details and ability for in-depth research and analysis
  • Highly motivated with the ability to resolve technical issues, develop and implement corrective solutions, be able to quickly adapt and respond effectively to changes

 

EXPERIENCE

 

  • Bachelors degree with 6+ years/Masters degree with 4+ years (for Senior RA 1) or Bachelors degree with 8+ years/Masters degree with 6+ years (for Senior RA 2) of experience in a pharmaceutical R&D environment or in a University
  • Experience with formulation development activities (pH profiling, excipient/formulation prototype screening, compatibility evaluation of drug product with fill-finish processing materials and container closure components, managing stability programs and other studies relevant to ensuring robust and scalable formulation selection is required.
  • Must be able to efficiently plan, design and execute experiments independently
  • Excellent analytical skills and ability to present results in both oral and written formats
  • Must be able to employ various analytical methods (HPLC, calorimetry, Karl Fischer, spectrophotometry, light scattering, Freeze Drying Microscopy, etc.) to screen and characterize drug products


We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, disability status, protected veteran status, or any other characteristic protected by law.