Associate Director, Protein Homeostasis Biochemistry/Biophysics
At Bristol Myers Squibb, we are inspired by a single vision – transforming patients’ lives through science. In oncology, hematology, immunology and cardiovascular disease – and one of the most diverse and promising pipelines in the industry – each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.
BMS is a leader in the discovery and development of novel therapies that exploit targeted protein degradation. The biochemical and biophysical characterization of these induced protein complexes is critical to our protein homeostasis (PH) research, as they will enable our understanding of mechanisms of action that will enable compound design and predictions about new biological targets for our drug discovery efforts. A deep focus in Oncology, with additional efforts in other therapeutic areas of unmet need, places our research squarely within projects of intense biomedical interest.
The team leader will direct the research of a talented group of Biochemists and Biophysicists and will focus their experience and expertise in the PH field. There is opportunity to have a real-time, high-value impact on the ongoing projects and chart the future of our research efforts by, for example, uncovering mechanisms of action, defining binding modes, and identifying target degrons. The leader will interface with Structural Biology, Chemistry, Molecular and Cellular Biology, and Computational-Aided Drug Design scientists that are dedicated to our PH projects. There are additional opportunities to interact across our Biochemistry and Biophysics community of scientists at other BMS sites. We are seeking a passionate leader who strives to uncover impactful mechanistic insights to benefit a burgeoning portfolio of PH targets, in order to help bring novel therapies to patients.
- Build and lead an internal team of 5 PH scientists focused on Biochemical and Biophysical studies
- Participate in a key alliance established to identify neosubstrates across cell lines representing human tumors and other diseases
- Plan, execute, and report on studies resulting in novel structures for CRBN E3 Ligase Modulators (CELMoDs) and Ligand Directed Degraders (LDDs)
- Lead Biochemical and Biophysical efforts pursuing novel ligands for E3 ligases
- Represent the PH Biochemistry and Biophysics Team at project level and departmental meetings
- Lead and participate in departmental initiatives and represent PH Biochemistry and Biophysics on cross-functional initiatives / work streams / taskforces
- Interact closely with Structural Biologists, Cell Biologists, and Chemists on drug discovery teams
- Work with Business Development teams and provide critical expertise to assess external opportunities
- Provide mentorship and career development guidance to staff
- A PhD with post-doctoral training in structural biology
- 8+ years of experience in an academic and/or industrial setting innovating strategies to characterize the mechanisms of action and binding modes of protein/protein and protein/ligand complexes and/or multi-subunit complexes
- In-depth knowledge of current practices, instrumentation, and issues for answering key biochemical and biophysical questions with a focus on protein complexes and enzymes
- Demonstrated expertise in biophysics, biochemistry and bioassay development, with working knowledge of proteomics and protein expression
- Strong written and oral communication skills necessary to deliver scientific results and presentations clearly
- Demonstrated ability to thrive in a multidisciplinary team and inspire mutually-beneficial collaborations to drive the development of PH therapeutics
- Keen desire to grow and develop the careers of team members
- Deep experience in the structural aspects of protein degradation pathways is strongly preferred
- Local and international travel for conferences may be required depending on project needs up to 5% of the time
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
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