Senior/Principal Scientist, Immunohistochenistry

San Francisco Bay Area
Jun 14, 2021
Required Education
Position Type
Full time

Our client seeking to hire a Senior Scientist/Principal Scientist for their Immunohistochemistry and Analytical Histology group. This position will afford the successful individual an opportunity to help discover and develop innovative drugs to modulate an emerging and exciting biological concept in diseases of aging and to translate our science into a pipeline of differentiated medicines.

The successful candidate will be a strong individual contributor and leader. The duties of the job include experimental design and execution, analysis and interpretation of data, regular presentations (verbal/written) of results and interpretation at group, project team, and Discovery team meetings. Depending on management experience the candidate could be responsible for overseeing activity of and mentoring junior staff. Title/compensation will be based on experience.


  • Experimental design, execution, analysis and interpretation of histology experiments.
  • Perform histological stains, IHC / IF, or ISH on mouse and human tissue utilizing both manual and automated platforms.
  • Slide imaging and fluorescence microscopy.
  • Image quantification and analysis.
  • Experimental write up and communication.
  • Manage companywide project requests and provide cross-functional communication for histology-related projects.
  • Develop and implement new assays, functionality and technology for project needs.
  • Oversee sample/data organization logistics and assay/data QC.

Work hands-on in the lab to contribute to project execution and lab maintenance.


  • Ph.D. with 5-8 years of scientific experience or Bachelor’s/Master’s degree with >10 years of post-graduate work (at least 3 years industry experience). Degree in medical technology, clinical laboratory, chemical, physical or biological science is essential.
  • Minimum 5 years of experience as a histology technologist.
  • Thorough understanding of all aspects of histology/pathology.
  • Proficiency with histological image analysis and statistical analysis, experience with image quantification tools such as Visiopharm.
  • Experience with IHC autostainers (e.g. Leica Bond, Roche Ventana).
  • Familiarity with multicolor IF and other multiplexing technologies.
  • Familiarity with ISH (knowledge of the ACD platform is a plus).
  • Experience with slide scanning. Zeiss Axioscan Z1 experience a plus.
  • Track record of managing, developing, and mentoring junior scientists and research associates preferred.
  • Creativity and the ability to lead and/or work within an interdisciplinary team in order to achieve technical and corporate milestones.