Research Associate/Senior Research Associate, Immuno-Oncology

Location
Philadelphia, PA
Posted
Jun 14, 2021
Ref
2523795751
Hotbed
Pharm Country
Required Education
Bachelors Degree
Position Type
Full time

Position Title: Research Associate/Senior Research Associate, Immuno-Oncology

Position Level: Associate Level

Reports to: Scientist, Immuno-Oncology

 

Company Background:

Century Therapeutics is developing novel allogeneic living cell products for oncology that overcome the limitations of current cell therapies. Century’s genetically-engineered, universal iPSC-derived immune effector cell products are designed to specifically target hematologic and solid tumor cancers. Our commitment to developing off-the-shelf cell therapies will expand patient access and provide an unparalleled opportunity to advance the course of cancer care. 

 

Century’s foundational technology is built on induced pluripotent stem cells (iPSCs) that have unlimited self-renewing capacity. This enables complex cellular engineering to produce controlled cell banks of modified cells that can be expanded and differentiated into desired immune effector cells, which can supply vast amounts of allogeneic, homogeneous therapeutic products. This platform differentiates Century from other approaches that utilize non-renewable donor-derived cells.

 

Role:

We are seeking a highly motivated and creative research associate who is comfortable working in a fast-paced environment. Candidate should have significant experience in cell culture and cell biology assays to help us advance our universal iPSC-derived allogeneic cell products for targeting hematological and solid tumors. He/she will be responsible for utilizing existing and optimizing new protocols and technologies aimed to interrogate our CAR NK/T cell prototypes. The ideal candidate will work closely and collaboratively with colleagues across different functional teams to achieve collective corporate goals.


Responsibilities:

  • Maintain long-term cell cultures.
  • Isolate different immune cell subsets from peripheral blood mononuclear cells (PBMCs).
  • Perform bioassays such as ELISA, MSD, immunohistochemistry, microscopy, co-culture/killing assays.
  • Utilize flow cytometry to analyze samples.
  • Accurately record and document results in a timely, detailed, and organized manner.
  • Communicate clearly and effectively with team members.
  • Requires occasional weekend work.

 

Qualifications:

BS in relevant area (biology, biochemistry, chemistry, molecular biology, etc.) is required, and 2 years of work experience is preferred but not required. Candidates with MS in biological sciences with 0 - 2 years of experience will also be considered.

 

Requirements:

Essential

  • Ability to work in a fast-paced environment, adapt to changes, and learn quickly
  • Strong communication skills and good team player
  • Experience with aseptic cell culture methods (primary cells or cell lines)

Preferred

  • Experience with primary human immune cells such as PBMCs. Ability to process PBMCs and perform magnetic isolations is a plus
  • Flow cytometry experience including staining, cytometer operation, and data analysis
  • Proficiency in molecular biology techniques including PCR, ELISA, MSD, Western Blotting, immunohistochemistry, and fluorescence microscopy