Research Associate III (In Vivo/Oncology)

Location
San Francisco, CA, United States
Posted
Jun 13, 2021
Ref
5319-360-R
Hotbed
Biotech Bay
Required Education
Bachelors Degree
Position Type
Full time
Position Overview

Nektar has an exciting opportunity for a Research Associate III (In Vivo/Oncology) to join their Research Biology Pharmacology Team.

We are seeking a highly motivated individual who is highly proficient in vivo tumor models establishment and execution and in vivo drug administration by multiple routes, disease scoring and tissue sample collection for ex vivo assays.

Responsibilities:
  • Conduct in vivo pharmacological evaluation of test agents (small molecules and biologics) in syngeneic and xenograft tumor models.
  • Proven skills in cell culture and tumor inoculation with cell lines
  • Conduct in vivo oncology models, administering test articles (i.v., s.c., i.p., i.d. and p.o.), making in vivo tumor measurements, collecting samples for ex vivo assays. May assist in sample processing, homogenization, and generation of single-cell suspensions for ex vivo analysis including flow cytometry, blood and plasma cytokine measurements.
  • Candidate will be responsible for entering and assist in analysis of data from concurrent multiple tumor studies in a timely manner and must be able to communicate experimental results orally and assist in reports and regulatory documentation writing.
  • Maintain familiarity with current disease relevant in vivo models for testing of mechanism of action and efficacy of novel drug candidates to support preclinical development and investigational new drug application filings.
  • Contribute to development of new xenograft and syngeneic liquid and solid tumor models (murine).
  • Exercises technical discretion in interpreting study designs, execution and interpretation of experiments that contribute to project strategies.
  • Performs research and/or development of new protocols independently and in collaboration with others in a highly integrated collaborative team environment with strong sense of individual responsibility.
  • Maintains a high level of professional expertise through familiarity with scientific literature.
  • Ensures compliance with good laboratory practices, AAALAC, IACUC, and other regulatory guidelines.
Minimum Qualification Requirements:

A minimum of a Bachelor's degree in a scientific discipline is required. Equivalent experience may be accepted. A minimum of 5 years work experience in a research and/or development environment is required.

Additional Requirements Include:
  • Highly skilled in conducting in vivo oncology models, administering test articles (i.v., s.c., i.p., i.d. and p.o. required), making in vivo tumor measurements, collecting samples for ex vivo assays.
  • Experience in preparing basic formulations and dosing solutions is essential.
  • Understands and implements study protocols according to AAALAC and other guidelines.
  • Ability to work collaboratively within a team, provide and receive technical assistance to/from others in a wide range of laboratory-based activities/techniques, while displaying strong organizational and timely record-keeping skills.
  • Interpersonal skills conductive to strong team integration and willingness to learn new techniques are essential.
  • Ability to multi-task and perform work with a high degree of attention to detail while supporting programs in a fast-paced environment.
  • Requires occasional weekend hours.
  • Must have excellent observational and analytical skills, strong organizational skills, and significant hands-on laboratory experience.
  • Excellent oral and written communication skills, is preferred. Experience working in an FDA-regulated environment is highly desired.
Performance of tasks essential to the job function may require the employee to work directly with, handle, or otherwise come into contact with chemicals or pharmaceutical agents. Employees must be able to wear a respiratory protection (filtering facepiece, 1/2 face, full-face, or powered air purifying respirator, supplied air, or self contained breathing apparatus) for certain tasks essential to the job function. Employees must be able to able to accurately detect color and have 20/20 vision (with/without corrective lenses). Employees may be required to enroll in a medical surveillance program based on the potential exposure to certain health hazards encountered as a result of their job function

We are an Equal Opportunity Employer and do not discriminate against applicants due to race, ethnicity, gender, veteran status, or on the basis of disability or any other federal, state or local protected class. Nektar Therapeutics will consider for employment qualified applicants with criminal histories in the manner proscribed by the San Francisco Fair Chance Ordinance.